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Details on Person CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 ...
| Class:Id | Summation:349443 |
|---|---|
| _displayName | CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 ... |
| _timestamp | 2015-10-16 14:14:39 |
| created | [InstanceEdit:349466] Matthews, L, 2008-05-07 22:49:21 |
| literatureReference | [LiteratureReference:349453] ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage |
| modified | [InstanceEdit:349488] Matthews, L, 2008-05-07 23:02:21 [InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:6804951] Orlic-Milacic, Marija, 2015-10-16 |
| text | CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 at serine residues S342 and S367 in vivo. CHEK2-mediated phosphorylation stimulates MDM4 ubiquitination by MDM2 and subsequent degradation (Chen et al. 2005). |
| (summation) | [Reaction:349426] Phosphorylation of MDM4 by CHEK2 [Homo sapiens] |
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No pathways have been reviewed or authored by CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 ... (349443)
