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Details on Person FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling

Class:Id	Reaction:3465459
_displayName	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
_doRelease	TRUE
_timestamp	2013-05-31 09:49:34
authored	[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:3465480] Shamovsky, V, 2013-05-17
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
figure	[Figure:141227] /figures/FasL_Fas_FADD_Caspase8.jpg
input	[Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3371356] CFLAR(1-480) [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:3465456] Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL [LiteratureReference:3465425] The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex [LiteratureReference:3465476] NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP [LiteratureReference:3465382] Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway
modified	[InstanceEdit:3508358] Shamovsky, V, 2013-05-17 [InstanceEdit:3597633] Shamovsky, V, 2013-05-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
output	[Complex:3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Homo sapiens] [Reaction:83650] FasL:Fas binds FADD [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654514] R-HSA-3465459.2
summation	[Summation:3465432] Pro-caspase-8 and FLIP(L) are recruited to FAS/CD95 receptor...
(hasEvent)	[Pathway:3371378] Regulation by c-FLIP [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:3465448] Caspase-8 and FLIP(L) processing at DISC [Homo sapiens]
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No pathways have been reviewed or authored by FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (3465459)