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Details on Person FLIP(S) and procaspase-8 form heterodimer

Class:Id	Reaction:3465429
_displayName	FLIP(S) and procaspase-8 form heterodimer
_doRelease	TRUE
_timestamp	2020-08-30 11:54:26
authored	[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3465480] Shamovsky, V, 2013-05-17
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
goBiologicalProcess	[GO_BiologicalProcess:3446166] negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
input	[Complex:3465443] DISC:procaspase-8 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3465357] FLIP(S) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1267786] FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity [LiteratureReference:3465423] Association of TRAF2 with the short form of cellular FLICE-like inhibitory protein prevents TNFR1-mediated apoptosis [LiteratureReference:3465503] NF-kappaB signals induce the expression of c-FLIP [LiteratureReference:3465385] The role of c-FLIP in modulation of CD95-induced apoptosis
modified	[InstanceEdit:3508358] Shamovsky, V, 2013-05-17 [InstanceEdit:3597633] Shamovsky, V, 2013-05-22 [InstanceEdit:5675027] Shamovsky, V, 2015-02-15 [InstanceEdit:9698845] Shamovsky, Veronica, 2020-08-30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLIP(S) and procaspase-8 form heterodimer
output	[Complex:3465352] DISC:procaspase-8:FLIP(S) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Homo sapiens] [Reaction:83650] FasL:Fas binds FADD [Homo sapiens] [Reaction:75240] TRADD:TRAF2:RIP1:FADD binds pro-caspase 8 [Homo sapiens] [Reaction:140978] TRADD:TRAF2:RIP1 binds FADD [Homo sapiens] [Reaction:75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 [Homo sapiens] [Reaction:75187] TRAIL:TRAIL receptor trimers bind FADD [Homo sapiens]
releaseDate	2015-03-19
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654525] R-HSA-3465429.3
summation	[Summation:3465395] The short form of cellular FLIP (FLIP(S) or c-FLIPS) has two...
(hasEvent)	[Pathway:5218900] CASP8 activity is inhibited [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776755] Update Tracker - [Reaction:3465429] FLIP(S) and procaspase-8 form heterodimer - v74:[modifyText] [_UpdateTracker:9785169] Update Tracker - [Reaction:3465429] FLIP(S) and procaspase-8 form heterodimer - v52:[modifyText]
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