Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Pulldown experiments in colorectal cancer cells show an inte...

Class:IdSummation:3451151
_displayNamePulldown experiments in colorectal cancer cells show an inte...
_timestamp2013-05-16 16:42:11
created[InstanceEdit:3451149] Rothfels, K, 2013-05-16
textPulldown experiments in colorectal cancer cells show an interaction between the C-terminal region of beta-catenin (ARM domains 11 and 12 through the C terminal) with a number of TRRAP-KAT5 HAT complex members including TRRAP, TIP49, p400 and KAT5 (TIP60), among others (Sierra et al, 2006; Bauer et al, 1998; Bauer et al, 2000; Feng et al, 2003). KAT5 and TIP49 have been shown to directly regulate WNT target genes in vivo and are associated with increased H4 acetylation (Bauer et al, 2000; Feng et al, 2003; Kim et al, 2005).
(summation)[Reaction:3451153] Beta-catenin recruits TRRAP/KAT5 HAT components [Homo sapiens]
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