Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-...
| Class:Id | Summation:3451148 |
|---|---|
| _displayName | TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-... |
| _timestamp | 2014-01-17 17:15:13 |
| created | [InstanceEdit:3451149] Rothfels, K, 2013-05-16 |
| modified | [InstanceEdit:5229357] Rothfels, K, 2014-01-17 |
| text | TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-2 promoter in vivo in HEK293 cells as assessed by ChIP. Expression of a dominant negative form of TIP49 in rat epithelial cells is associated with a decrease in both histone H4 acetylation at the ITF-2 promoter and in ITF-2 gene expression. These results suggest that a TIP49-containing HAT complex may play a role in promoting WNT-responsive ITF-2 expression, although more functional studies will be required to elucidate the mechanism (Feng et al, 2003). |
| (summation) | [Reaction:3451147] KAT5 HAT complex acetylates TCF4 gene at histone H4 [Homo sapiens] |
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No pathways have been reviewed or authored by TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-... (3451148)
