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Details on Person KAT5 HAT complex acetylates TCF4 gene at histone H4

Class:Id	Reaction:3451147
_displayName	KAT5 HAT complex acetylates TCF4 gene at histone H4
_doRelease	TRUE
_timestamp	2014-11-20 02:30:16
authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:3451130] histone acetyltransferase activity of TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3451149] Rothfels, K, 2013-05-16
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
inferredFrom	[Reaction:3451144] KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4 [Homo sapiens]
input	[Complex:3451116] TCF4 gene:nucleosome [nucleoplasm] [Homo sapiens] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm]
isChimeric	FALSE
modified	[InstanceEdit:3774848] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518446] Rothfels, K, 2013-09-03 [InstanceEdit:4655156] Rothfels, K, 2013-10-02 [InstanceEdit:5097374] Rothfels, K, 2013-11-11 [InstanceEdit:5146706] Rothfels, K, 2013-11-18 [InstanceEdit:5251602] Rothfels, K, 2014-02-04 [InstanceEdit:5323576] Rothfels, K, 2014-02-15 [InstanceEdit:5576917] Rothfels, Karen, 2014-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	KAT5 HAT complex acetylates TCF4 gene at histone H4
output	[Complex:3451134] TCF4 gene:acetyl H4 nucleosome [nucleoplasm] [Homo sapiens] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm]
precedingEvent	[Reaction:3451153] Beta-catenin recruits TRRAP/KAT5 HAT components [Homo sapiens] [Reaction:3299569] Beta-catenin displaces TLE:HDAC1 from TCF/LEF [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644201] R-HSA-3451147.2
summation	[Summation:3451148] TIP49, TRRAP, TCF7L2 (TCF4) and KAT5 are present at the ITF-...
(hasEvent)	[Pathway:201722] Formation of the beta-catenin:TCF transactivating complex [Homo sapiens]
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