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Details on Person KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4

Class:Id	Reaction:3451144
_displayName	KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4
_doRelease	TRUE
_timestamp	2014-11-20 02:29:35
authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:3451127] histone acetyltransferase activity of LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3451145] Rothfels, K, 2013-05-16
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input	[SimpleEntity:113560] Ac-CoA [nucleoplasm] [SimpleEntity:113560] Ac-CoA [nucleoplasm] [Complex:3451115] TCF4 gene:nucleosome [nucleoplasm] [Rattus norvegicus]
isChimeric	TRUE
literatureReference	[LiteratureReference:3451146] TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling [LiteratureReference:3451143] ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation
modified	[InstanceEdit:3774847] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518445] Rothfels, K, 2013-09-03 [InstanceEdit:4655155] Rothfels, K, 2013-10-02 [InstanceEdit:5097275] Rothfels, K, 2013-11-11 [InstanceEdit:5146705] Rothfels, K, 2013-11-18 [InstanceEdit:5228713] Rothfels, K, 2014-01-14 [InstanceEdit:5251601] Rothfels, K, 2014-02-04 [InstanceEdit:5323661] Rothfels, K, 2014-02-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4
output	[SimpleEntity:2485002] CoA-SH [nucleoplasm] [SimpleEntity:2485002] CoA-SH [nucleoplasm] [Complex:3451136] TCF4 gene:acetyl H4 nucleosome [nucleoplasm] [Rattus norvegicus]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens [Species:48895] Rattus norvegicus
stableIdentifier	[StableIdentifier:5644175] R-NUL-3451144.2
summation	[Summation:3451141] ChIP studies in HEK293 cells show that RUVBL1(TIP49), TRRAP,...
(inferredFrom)	[Reaction:3451147] KAT5 HAT complex acetylates TCF4 gene at histone H4 [Homo sapiens]
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No pathways have been reviewed or authored by KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4 (3451144)