Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:D3KZG3 tmc-1
| Class:Id | ReferenceGeneProduct:3445785 |
|---|---|
| _chainChangeLog | chain:1-1285 added on Fri February 6 2015 |
| _displayName | UniProt:D3KZG3 tmc-1 |
| _timestamp | 2024-08-09 18:57:29 |
| chain | chain:1-1285 |
| checksum | BC5A3332464D6D36 |
| comment | FUNCTION Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex (PubMed:36224384). The MET complex is composed of symmetric dimeric MET channels, each channel comprising two copies of pore-forming ion-conducting transmembrane TMC subunits and auxiliary proteins including the transmembrane inner ear protein/tmie, the calcium-binding protein/calm-1 and arrestin domain protein arrd-6 (PubMed:36224384). Sodium ions are the most permeable, whereas calcium and potassium have lower indices (PubMed:23364694). Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl.CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)SUBUNIT Homodimer (PubMed:36224384). Interacts with calm-1 and tmie to form the MET channel (PubMed:36224384).SUBCELLULAR LOCATION Expressed in the ASH polymodal avoidance neurons. Also expressed in other sensory neurons, including the ADF, ASE, ADL, AQR, PQR, URX and PHA cells.DOMAIN Contains ten transmembrane domains with putative domains TM4-TM8 that line the channel pore.DOMAIN Interacts with tmie through transmembrane domains TM6 and TM8 and via a tmie palmitoylated residue.DOMAIN Interacts with calm-1 through cytosolic helical features including the helices H1 to H3, and H5-H6.DISRUPTION PHENOTYPE No apparent defect in nose touch avoidance but mutants show strong defects in the avoidance of NaCl concentrations above 100 mM. Responses to other soluble repellents as well as to hyperosmolarity are indistinguishable from wild-type animals.SIMILARITY Belongs to the TMC family. |
| created | [InstanceEdit:3445779] Weiser, JD |
| description | recommendedName: Transmembrane channel-like protein 1 |
| geneName | tmc-1 T13G4.3 |
| identifier | D3KZG3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | tmc-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TMC1_CAEEL G4S885 |
| sequenceLength | 1285 |
| species | [Species:68320] Caenorhabditis elegans |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:D3KZG3 tmc-1 (3445785)
