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Details on Person UniProt:Q23571 dbt-1
| Class:Id | ReferenceGeneProduct:3445784 |
|---|---|
| _chainChangeLog | transit peptide:1- added on Fri February 6 2015;chain:-448 added on Fri February 6 2015 |
| _displayName | UniProt:Q23571 dbt-1 |
| _timestamp | 2026-02-20 22:46:49 |
| chain | transit peptide:1- chain:-448 |
| checksum | E3C0FC5B2C5946AA |
| comment | FUNCTION The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2) (By similarity). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component (By similarity). Required for the catabolism of branched-chain amino acids and the subsequent synthesis of monomethyl branched-chain fatty acids, which are important for regulating postembryonic growth (PubMed:26683372).CATALYTIC ACTIVITY N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoACATALYTIC ACTIVITY N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 3-methylbutanoyl-CoA = N(6)-[(R)-S(8)-3-methylbutanoyldihydrolipoyl]-L-lysyl-[protein] + CoACATALYTIC ACTIVITY (2S)-2-methylbutanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = N(6)-{(R)-S(8)-[(2S)-2-methylbutanoyl]dihydrolipoyl}-L-lysyl-[protein] + CoACOFACTOR Binds 1 lipoyl cofactor covalently.SUBCELLULAR LOCATION Localizes to puncta within the cytosol which is consistent with its expected location in mitochondria.TISSUE SPECIFICITY Ubiquitously expressed.DISRUPTION PHENOTYPE RNAi-mediated knockdown results in reduced monomethyl branched-chain fatty acid generation and also results in larval arrest in the subsequent generation.SIMILARITY Belongs to the 2-oxoacid dehydrogenase family. |
| created | [InstanceEdit:3445779] Weiser, JD |
| description | recommendedName: fullName evidence="8"Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial ecNumber evidence="1"2.3.1.168 alternativeName: Branched-chain alpha-keto acid dehydrogenase complex component E2 alternativeName: fullName evidence="9"Dihydrolipoamide branched-chain transacylase E2 |
| geneName | dbt-1 ZK669.4 |
| identifier | Q23571 |
| isSequenceChanged | FALSE |
| keyword | Acyltransferase Cell projection Cytoplasm Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Lipoyl Mitochondrion Reference proteome Transferase Transit peptide |
| modified | [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | dbt-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ODB2_CAEEL |
| sequenceLength | 448 |
| species | [Species:68320] Caenorhabditis elegans |
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No pathways have been reviewed or authored by UniProt:Q23571 dbt-1 (3445784)
