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Details on Person DBC1 is phosphorylated by ATM/ART

Class:Id	Reaction:3371567
_displayName	DBC1 is phosphorylated by ATM/ART
_doRelease	TRUE
_timestamp	2018-08-09 02:49:43
authored	[InstanceEdit:4793943] Shamovsky, V, 2013-10-28
catalystActivity	[CatalystActivity:421861] protein serine/threonine kinase activity of ATM/ATR kinase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
edited	[InstanceEdit:5324627] Shamovsky, V, 2014-02-17
input	[EntityWithAccessionedSequence:3371479] DBC1 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:3371587] DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage [LiteratureReference:3371487] Regulation of SIRT1 activity by genotoxic stress
modified	[InstanceEdit:5082424] Shamovsky, V, 2013-11-05 [InstanceEdit:5083129] Shamovsky, V, 2013-11-05 [InstanceEdit:5096434] Shamovsky, V, 2013-11-09 [InstanceEdit:5148862] Shamovsky, V, 2013-11-18 [InstanceEdit:5324681] Shamovsky, V, 2014-02-17 [InstanceEdit:6789540] Shamovsky, Veronica, 2015-08-03 [InstanceEdit:9615895] Shamovsky, Veronica, 2018-08-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DBC1 is phosphorylated by ATM/ART
output	[EntityWithAccessionedSequence:3371569] p-T454-DBC1 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5324628] Pani, Bibhusita, 2014-02-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644842] R-HSA-3371567.4
summation	[Summation:5096417] The stress-induced DBC1-SIRT1 interaction required the ATM/A...
(hasEvent)	[Pathway:3371453] Regulation of HSF1-mediated heat shock response [Homo sapiens]
(precedingEvent)	[Reaction:3371537] DBC1 binds SIRT1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779279] Update Tracker - [Reaction:3371567] DBC1 is phosphorylated by ATM/ART - v66:[addInput, addOutput]
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No pathways have been reviewed or authored by DBC1 is phosphorylated by ATM/ART (3371567)