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Details on Person TNF-α is cleaved by ADAM17 (TACE)

Class:IdReaction:3371385
_displayNameTNF-α is cleaved by ADAM17 (TACE)
_doReleaseTRUE
_timestamp2022-06-30 04:18:49
authored[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
catalystActivity[CatalystActivity:1251983] metalloendopeptidase activity of ADAM17 [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:3371404] Shamovsky, V, 2013-05-13
edited[InstanceEdit:3632865] Shamovsky, V, 2013-05-28
input[Complex:3371351] TNF(1-233) trimer [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3465559] Release of tumour necrosis factor alpha (TNFalpha) by TNFalpha cleaving enzyme (TACE) in response to septic stimuli in vitro
[LiteratureReference:3465568] Unlike for human monocytes after LPS activation, release of TNF-? by THP-1 cells is produced by a TACE catalytically different from constitutive TACE
modified[InstanceEdit:3465520] Shamovsky, V, 2013-05-17
[InstanceEdit:3465577] Shamovsky, V, 2013-05-17
[InstanceEdit:3597633] Shamovsky, V, 2013-05-22
[InstanceEdit:3632866] Shamovsky, V, 2013-05-28
[InstanceEdit:3632867] Shamovsky, V, 2013-05-28
[InstanceEdit:5657736] Shamovsky, V, 2014-12-16
[InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25
[InstanceEdit:8863091] Jupe, Steve, 2016-03-04
[InstanceEdit:9794234] Shamovsky, Veronica, 2022-06-30
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTNF-α is cleaved by ADAM17 (TACE)
output[Complex:3371370] TNF-α trimer, soluble form [extracellular region] [Homo sapiens]
[Complex:8863104] TNF(1-76) trimer [plasma membrane] [Homo sapiens]
releaseDate2013-06-11
reviewed[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3654338] R-HSA-3371385.5
summation[Summation:3465572] TNF-α is initially synthesized as a 26kDa transmembrane prot...
(hasEvent)[Pathway:75893] TNF signaling [Homo sapiens]
(precedingEvent)[Reaction:3371353] Soluble TNF-α binds TNFR1 [Homo sapiens]
[Reaction:9714924] TNF-alpha inhibitors bind to soluble TNF trimer [Homo sapiens]
[Reaction:9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9783267] Update Tracker - [Reaction:3371385] TNF-alpha is cleaved by ADAM17 (TACE) - v57:[addOutput]
[_UpdateTracker:9784779] Update Tracker - [Reaction:3371385] TNF-alpha is cleaved by ADAM17 (TACE) - v53:[modifyText]
[_UpdateTracker:9785300] Update Tracker - [Reaction:3371385] TNF-alpha is cleaved by ADAM17 (TACE) - v52:[modifyText]
[_UpdateTracker:9847041] Update Tracker - [Reaction:3371385] TNF-α is cleaved by ADAM17 (TACE) - v82:[modifyText]
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