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Details on Person FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling

Class:Id	Reaction:3371359
_displayName	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
_doRelease	TRUE
_timestamp	2014-11-11 05:45:38
authored	[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:3371404] Shamovsky, V, 2013-05-13
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
input	[EntityWithAccessionedSequence:3371356] CFLAR(1-480) [cytosol] [Homo sapiens] [Complex:5637468] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:3465422] Cellular FLIP(L) plays a survival role and regulates morphogenesis in breast epithelial cells [LiteratureReference:3465385] The role of c-FLIP in modulation of CD95-induced apoptosis [LiteratureReference:3465382] Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway [LiteratureReference:3465460] Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis
modified	[InstanceEdit:3465518] Shamovsky, V, 2013-05-17 [InstanceEdit:3508358] Shamovsky, V, 2013-05-17 [InstanceEdit:3597633] Shamovsky, V, 2013-05-22 [InstanceEdit:5637557] Shamovsky, Veronica, 2014-11-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
output	[Complex:3371390] TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:75146] TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 [Homo sapiens] [Reaction:75187] TRAIL:TRAIL receptor trimers bind FADD [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654456] R-HSA-3371359.2
summation	[Summation:3465446] Pro-caspase-8 and FLIP(L) are recruited to the DISC. Followi...
(hasEvent)	[Pathway:3371378] Regulation by c-FLIP [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:3465448] Caspase-8 and FLIP(L) processing at DISC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785895] Update Tracker - [Reaction:3371359] FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling - v51:[add_removeInput]
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