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Details on Person GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Class:Id	Reaction:3341397
_displayName	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
_doRelease	TRUE
_timestamp	2014-11-20 02:30:39
authored	[InstanceEdit:3323087] May, B, 2013-05-09
catalystActivity	[CatalystActivity:3341271] glutathione peroxidase activity of GPX3 tetramer [extracellular region]
catalystActivityReference	[CatalystActivityReference:9643575] glutathione peroxidase activity of GPX3 tetramer [extracellular region] Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:3341366] May, B, 2013-05-11
edited	[InstanceEdit:3323087] May, B, 2013-05-09
input	[SimpleEntity:1247892] GSH [extracellular region] [SimpleEntity:1247892] GSH [extracellular region] [SimpleEntity:351629] H2O2 [extracellular region]
literatureReference	[LiteratureReference:3341353] Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells [LiteratureReference:3341385] Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells [LiteratureReference:3341378] Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase [LiteratureReference:3341357] Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme
modified	[InstanceEdit:3343761] May, B, 2013-05-12 [InstanceEdit:4415003] May, B, 2013-08-23 [InstanceEdit:4420243] May, B, 2013-08-31 [InstanceEdit:4837349] May, B, 2013-11-01 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
output	[SimpleEntity:3341331] GSSG [extracellular region] [SimpleEntity:109276] H2O [extracellular region] [SimpleEntity:109276] H2O [extracellular region]
precedingEvent	[Reaction:3299682] SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular) [Homo sapiens] [BlackBoxEvent:4837364] Secretion of SOD3 [Homo sapiens]
releaseDate	2013-12-04
reviewed	[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644213] R-HSA-3341397.3
summation	[Summation:3343756] Glutathione peroxidase 3 (GPX3) in plasma reduces hydrogen p...
(hasEvent)	[Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens]
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No pathways have been reviewed or authored by GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (3341397)