Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person HLCS R508W [cytosol]

Class:IdEntityWithAccessionedSequence:3325442
_displayNameHLCS R508W [cytosol]
_timestamp2025-08-19 23:11:36
compartment[Compartment:70101] cytosol
created[InstanceEdit:3325493] Jassal, B, 2013-05-09
disease[Disease:3325582] vitamin metabolic disorder
endCoordinate726
hasModifiedResidue[ReplacedResidue:3325468] L-arginine 508 replaced with L-tryptophan
modified[InstanceEdit:3662298] Jassal, B, 2013-06-07
[InstanceEdit:9964145] D'Eustachio, Peter, 2025-08-19
nameHLCS R508W
Biotin--protein ligase ecNumber6.3.4.-/ecNumber
BPL1_HUMAN
HLCS
referenceEntity[ReferenceGeneProduct:50938] UniProt:P50747 HLCS [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545497] R-HSA-3325442.2
startCoordinate1
(hasMember)[DefinedSet:3325449] HLCS mutants [cytosol] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964985] Update Tracker - [EntityWithAccessionedSequence:3325442] HLCS R508W [cytosol] - v94:[modifyEndCoordinate]
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No pathways have been reviewed or authored by HLCS R508W [cytosol] (3325442)