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Details on Person GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Class:IdReaction:3323013
_displayNameGPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
_doReleaseTRUE
_timestamp2021-03-05 02:29:12
authored[InstanceEdit:3323087] May, B, 2013-05-09
catalystActivity[CatalystActivity:3322984] glutathione peroxidase activity of GPX1 tetramer [mitochondrial matrix]
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:3323020] May, B, 2013-05-09
edited[InstanceEdit:3323087] May, B, 2013-05-09
input[SimpleEntity:1655887] GSH [mitochondrial matrix]
[SimpleEntity:1655887] GSH [mitochondrial matrix]
[SimpleEntity:1614617] H2O2 [mitochondrial matrix]
literatureReference[LiteratureReference:3323080] Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells
[LiteratureReference:3343681] The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase
[LiteratureReference:3343666] Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges
[LiteratureReference:9717162] Natural allelic variations in glutathione peroxidase-1 affect its subcellular localization and function
[LiteratureReference:9717165] ZNF143 transcription factor mediates cell survival through upregulation of the GPX1 activity in the mitochondrial respiratory dysfunction
modified[InstanceEdit:3341400] May, B, 2013-05-11
[InstanceEdit:3343703] May, B, 2013-05-12
[InstanceEdit:3343748] May, B, 2013-05-12
[InstanceEdit:4415003] May, B, 2013-08-23
[InstanceEdit:4420243] May, B, 2013-08-31
[InstanceEdit:4837349] May, B, 2013-11-01
[InstanceEdit:9717163] May, Bruce, 2021-03-05
[InstanceEdit:9717167] May, Bruce, 2021-03-05
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
output[SimpleEntity:1655882] GSSG [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
precedingEvent
releaseDate2013-12-04
reviewed[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5645143] R-HSA-3323013.3
summation[Summation:3343737] Glutathione peroxidase 1 (GPX1) located in the mitochondrial...
(hasEvent)[Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens]
(precedingEvent)[Reaction:3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776204] Update Tracker - [Reaction:3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - v77:[add_removeLiteratureReference, modifyText]
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