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Details on Person PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
Class:Id Reaction:3322995
_displayName PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
_doRelease TRUE
_timestamp 2014-11-20 02:50:31
authored [InstanceEdit:3323054] May, B, 2013-05-05
catalystActivity [CatalystActivity:3323063] thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix]
catalystActivityReference [CatalystActivityReference:9644071] thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix] Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state
compartment [Compartment:5460] mitochondrial matrix
created [InstanceEdit:3323020] May, B, 2013-05-09
edited [InstanceEdit:3323054] May, B, 2013-05-05
input [SimpleEntity:1614617] H2O2 [mitochondrial matrix] [EntityWithAccessionedSequence:3323048] TXN2 [mitochondrial matrix] [Homo sapiens]
isChimeric FALSE
literatureReference [LiteratureReference:3323082] Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study [LiteratureReference:3323067] Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state [LiteratureReference:3341370] Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family [LiteratureReference:3341394] Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro [LiteratureReference:3343706] Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution [LiteratureReference:3343736] Crystal structure of a dimeric oxidized form of human peroxiredoxin 5
modified [InstanceEdit:3341400] May, B, 2013-05-11 [InstanceEdit:3343748] May, B, 2013-05-12 [InstanceEdit:4415003] May, B, 2013-08-23 [InstanceEdit:4420243] May, B, 2013-08-31 [InstanceEdit:4837349] May, B, 2013-11-01 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
output [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [EntityWithAccessionedSequence:3323059] 2xHC-TXN2 [mitochondrial matrix] [Homo sapiens]
precedingEvent
releaseDate 2013-12-04
reviewed [InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:5644936] R-HSA-3322995.3
summation [Summation:3343707] Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matri...
(hasEvent) [Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens]
(precedingEvent) [Reaction:3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH [Homo sapiens]
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No pathways have been reviewed or authored by PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (3322995)