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Details on Person PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

Class:IdReaction:3322995
_displayNamePRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
_doReleaseTRUE
_timestamp2014-11-20 02:50:31
authored[InstanceEdit:3323054] May, B, 2013-05-05
catalystActivity[CatalystActivity:3323063] thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix]
catalystActivityReference[CatalystActivityReference:9644071] thioredoxin peroxidase activity of PRDX3,5 [mitochondrial matrix] Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state
compartment[Compartment:5460] mitochondrial matrix
created[InstanceEdit:3323020] May, B, 2013-05-09
edited[InstanceEdit:3323054] May, B, 2013-05-05
input[SimpleEntity:1614617] H2O2 [mitochondrial matrix]
[EntityWithAccessionedSequence:3323048] TXN2 [mitochondrial matrix] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3323082] Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study
[LiteratureReference:3323067] Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state
[LiteratureReference:3341370] Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family
[LiteratureReference:3341394] Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro
[LiteratureReference:3343706] Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution
[LiteratureReference:3343736] Crystal structure of a dimeric oxidized form of human peroxiredoxin 5
modified[InstanceEdit:3341400] May, B, 2013-05-11
[InstanceEdit:3343748] May, B, 2013-05-12
[InstanceEdit:4415003] May, B, 2013-08-23
[InstanceEdit:4420243] May, B, 2013-08-31
[InstanceEdit:4837349] May, B, 2013-11-01
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O
output[SimpleEntity:113521] H2O [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[EntityWithAccessionedSequence:3323059] 2xHC-TXN2 [mitochondrial matrix] [Homo sapiens]
precedingEvent
releaseDate2013-12-04
reviewed[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644936] R-HSA-3322995.3
summation[Summation:3343707] Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matri...
(hasEvent)[Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens]
(precedingEvent)[Reaction:3323050] TXNRD2 catalyzes the reduction of TXN2 by NADPH [Homo sapiens]
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No pathways have been reviewed or authored by PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (3322995)