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Details on Person The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

Class:IdLiteratureReference:3322328
_displayNameThe APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
_timestamp2013-05-03 17:48:34
author[Person:3322272] Sierra, Jose
[Person:3322300] Yoshida, Tomonori
[Person:3322211] Joazeiro, Claudio A
[Person:3322213] Jones, Katherine A
created[InstanceEdit:3322329] Rothfels, K, 2013-05-03
journalGenes Dev.
pages586-600
pubMedIdentifier16510874
titleThe APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
volume20
year2006
(literatureReference)[Complex:3361369] TCF/LEF:CTNNB1:BCL9:PYGO:MLL2:MEN1 complex [nucleoplasm] [Homo sapiens]
[Complex:3361754] TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] [Homo sapiens]
[Reaction:201712] Beta-catenin:TCF associates with BCL9 and PYGO [Homo sapiens]
[BlackBoxEvent:3361751] beta-catenin is replaced by repression complexes at the promoter [Homo sapiens]
[Reaction:3364014] Recruitment of MLL2 methyltransferase complex [Homo sapiens]
[Reaction:3364026] MLL2 complex trimethylates H3K4 at the MYC gene [Homo sapiens]
[BlackBoxEvent:3364042] APC promotes disassembly of beta-catenin transactivation complex [Homo sapiens]
[Reaction:3451153] Beta-catenin recruits TRRAP/KAT5 HAT components [Homo sapiens]
[Pathway:3769402] Deactivation of the beta-catenin transactivating complex [Homo sapiens]
[BlackBoxEvent:4411357] TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene [Homo sapiens]
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