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Details on Person GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a

Class:Id	Reaction:3322016
_displayName	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a
_doRelease	TRUE
_timestamp	2016-11-10 00:56:35
catalystActivity	[CatalystActivity:71577] 1,4-alpha-glucan branching enzyme activity of GBE1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643958] 1,4-alpha-glucan branching enzyme activity of GBE1 [cytosol] Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene.
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3322034] D'Eustachio, P, 2013-05-02
input	[Complex:3322056] polyGlc-GYG2:GYS2-a tetramer [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:70314] Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene. [LiteratureReference:3322039] Glycogen and its metabolism: some new developments and old themes
modified	[InstanceEdit:3322069] D'Eustachio, P, 2013-05-02 [InstanceEdit:4006041] D'Eustachio, P, 2013-07-25 [InstanceEdit:4006080] D'Eustachio, P, 2013-07-26 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a poly((1,4)-alpha-D-glucosyl) glycogenin2 => glycogen-glycogenin 2 (GYS2-a)
output	[Complex:3322011] glycogen-GYG2:GYS2-a tetramer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:3322009] GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 [Homo sapiens] [Reaction:3322014] Autoglucosylation of GYG2 complexed with GYS2-a [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4006079] Jassal, B, 2013-07-26
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:3322070] D'Eustachio, P, 2013-05-02
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545084] R-HSA-3322016.4
summation	[Summation:3322008] Cytosolic glycogen branching enzyme (GBE1) associated with g...
(hasEvent)	[Pathway:3322077] Glycogen synthesis [Homo sapiens]
(normalReaction)	[FailedReaction:3878762] Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver) [Homo sapiens]
(precedingEvent)	[Reaction:3780997] PPP1R3C binds to glycogen:GYG2:GYS2 [Homo sapiens]
(replacementInstances)	[_Deleted:3698014] Deletion of instance: 71610
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