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Details on Person GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2

Class:IdReaction:3322009
_displayNameGYS2 catalyzes the polyglucosylation of oligoGlc-GYG2
_doReleaseTRUE
_timestamp2024-12-11 21:03:49
catalystActivity[CatalystActivity:3322006] alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity of oligoGlc-GYG2:GYS2-a tetramer [cytosol]
catalystActivityReference[CatalystActivityReference:9643792] glycogen (starch) synthase activity of oligoGlc-GYG2:GYS2-a tetramer [cytosol] Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0
compartment[Compartment:70101] cytosol
created[InstanceEdit:3322034] D'Eustachio, P, 2013-05-02
crossReference[DatabaseIdentifier:9931459] RHEA:18550
input[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[Complex:3321999] oligoGlc-GYG2:GYS2-a tetramer [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9931477] D'Eustachio, Peter, 2024-12-11
literatureReference[LiteratureReference:199678] Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0
[LiteratureReference:3322039] Glycogen and its metabolism: some new developments and old themes
modified[InstanceEdit:3322069] D'Eustachio, P, 2013-05-02
[InstanceEdit:4006041] D'Eustachio, P, 2013-07-25
[InstanceEdit:4006080] D'Eustachio, P, 2013-07-26
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
[InstanceEdit:9931476] D'Eustachio, Peter, 2024-12-11
nameGYS2 catalyzes the polyglucosylation of oligoGlc-GYG2
((1->4)-alpha-D-glucosyl)(n) + UDP-alpha-D-glucose => ((1->4)-alpha-D-glucosyl)(n+1) + UDP + H(+)
8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin2 => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin2 (GYS2-a)
negativePrecedingEvent[NegativePrecedingEvent:9931460] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose
output[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[Complex:3322056] polyGlc-GYG2:GYS2-a tetramer [cytosol] [Homo sapiens]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2013-09-18
reviewed[InstanceEdit:4006079] Jassal, B, 2013-07-26
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:3322070] D'Eustachio, P, 2013-05-02
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545137] R-HSA-3322009.5
structureModified[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
summation[Summation:3322046] Unphosphorylated glycogen synthase 2 (GYS2-a) complexed with...
(hasEvent)[Pathway:3322077] Glycogen synthesis [Homo sapiens]
(normalReaction)[FailedReaction:3858506] Defective GYS2 does not transfer glucose to growing glycogen chains [Homo sapiens]
(precedingEvent)[Reaction:3322016] GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a [Homo sapiens]
(replacementInstances)[_Deleted:3698016] Deletion of instance: 71574
[_Deleted:3698017] Deletion of instance: 71602
(updatedInstance)[_UpdateTracker:9939669] Update Tracker - [Reaction:3322009] GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2 - v92:[removeOutput]
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