Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1

Class:IdReaction:3322001
_displayNameGYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
_doReleaseTRUE
_timestamp2024-12-11 21:03:48
catalystActivity[CatalystActivity:3322023] alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity of oligoGlc-GYG1:GYS1-a tetramer [cytosol]
catalystActivityReference[CatalystActivityReference:9643197] glycogen (starch) synthase activity of oligoGlc-GYG1:GYS1-a tetramer [cytosol] Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts
compartment[Compartment:70101] cytosol
created[InstanceEdit:3322034] D'Eustachio, P, 2013-05-02
crossReference[DatabaseIdentifier:9931459] RHEA:18550
input[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[SimpleEntity:29410] UDP-Glc [cytosol]
[Complex:3322035] oligoGlc-GYG1:GYS1-a tetramer [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9931477] D'Eustachio, Peter, 2024-12-11
literatureReference[LiteratureReference:3322036] Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts
[LiteratureReference:3322039] Glycogen and its metabolism: some new developments and old themes
modified[InstanceEdit:3322069] D'Eustachio, P, 2013-05-02
[InstanceEdit:4006041] D'Eustachio, P, 2013-07-25
[InstanceEdit:4006080] D'Eustachio, P, 2013-07-26
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
[InstanceEdit:9931476] D'Eustachio, Peter, 2024-12-11
nameGYS1 catalyzes the polyglucosylation of oligoGlc-GYG1
((1->4)-alpha-D-glucosyl)(n) + UDP-alpha-D-glucose => ((1->4)-alpha-D-glucosyl)(n+1) + UDP + H(+)
8 UDP-glucose + ((1,4)-alpha-D-glucosyl)4 glycogenin2 => 8 UDP + ((1,4)-alpha-D-glucosyl)8 glycogenin2 (GYS1-a)
negativePrecedingEvent[NegativePrecedingEvent:9931472] Abundant Molecules: UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose
output[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[SimpleEntity:110096] UDP [cytosol]
[Complex:3322054] polyGlc-GYG1:GYS1-a tetramer [cytosol] [Homo sapiens]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2013-09-18
reviewed[InstanceEdit:4006079] Jassal, B, 2013-07-26
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:3322070] D'Eustachio, P, 2013-05-02
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545064] R-HSA-3322001.5
structureModified[InstanceEdit:9931474] D'Eustachio, Peter, 2024-12-11
summation[Summation:3322028] Unphosphorylated glycogen synthase 1 (GYS1-a) complexed with...
(hasEvent)[Pathway:3322077] Glycogen synthesis [Homo sapiens]
(normalReaction)[FailedReaction:3828061] Defective GYS1 does not transfer glucose to growing glycogen chains [Homo sapiens]
(precedingEvent)[Reaction:3322005] GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a [Homo sapiens]
(replacementInstances)[_Deleted:3698016] Deletion of instance: 71574
[_Deleted:3698017] Deletion of instance: 71602
(updatedInstance)[_UpdateTracker:9939829] Update Tracker - [Reaction:3322001] GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 - v92:[removeOutput]
[Change default viewing format]
No pathways have been reviewed or authored by GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1 (3322001)
Follow Reactome