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Details on Person Defective MMADHC does not bind MMACHC:B12r

Class:IdFailedReaction:3318571
_displayNameDefective MMADHC does not bind MMACHC:B12r
_doReleaseTRUE
_timestamp2014-09-24 13:34:31
authored[InstanceEdit:3318614] Jassal, B, 2013-04-29
compartment[Compartment:70101] cytosol
created[InstanceEdit:3318614] Jassal, B, 2013-04-29
disease[Disease:3318582] methylmalonic aciduria and homocystinuria type cblD
edited[InstanceEdit:3318614] Jassal, B, 2013-04-29
entityFunctionalStatus[EntityFunctionalStatus:3318566] loss_of_function of MMADHC mutants [cytosol]
input[Complex:3095903] MMACHC:cob(II)alamin [cytosol] [Homo sapiens]
[DefinedSet:3318583] MMADHC mutants [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3149525] Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism
[LiteratureReference:3149487] Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism
[LiteratureReference:3149523] Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism
[LiteratureReference:3149550] Gene identification for the cblD defect of vitamin B12 metabolism
[LiteratureReference:3318597] The cblD defect causes either isolated or combined deficiency of methylcobalamin and adenosylcobalamin synthesis
modified[InstanceEdit:3318649] Jassal, B, 2013-04-29
[InstanceEdit:3359465] Jassal, B, 2013-05-13
[InstanceEdit:3446768] Jassal, B, 2013-05-15
[InstanceEdit:3446771] Jassal, B, 2013-05-15
[InstanceEdit:4093345] Jassal, B, 2013-08-14
[InstanceEdit:5624298] Jassal, Bijay, 2014-09-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective MMADHC does not bind MMACHC:B12r
normalReaction
releaseDate2013-09-18
reviewed[InstanceEdit:4093346] Watkins, D, 2013-08-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545322] R-HSA-3318571.2
summation[Summation:3318618] MMACHC:B12r (cob(II)alamin, vitamin B12r) binding to methylm...
(hasEvent)[Pathway:3359473] Defective MMADHC causes MMAHCD [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785870] Update Tracker - [FailedReaction:3318571] Defective MMADHC does not bind MMACHC:B12r - v51:[add_removeInput]
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