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Details on Person ATF2 (activating transcription factor 2) is a basic leucine ...

Class:IdSummation:3318391
_displayNameATF2 (activating transcription factor 2) is a basic leucine ...
_timestamp2013-10-04 10:34:05
created[InstanceEdit:3318432] Jupe, S, 2013-04-26
literatureReference[LiteratureReference:3318442] AP-1--Introductory remarks
[LiteratureReference:3318414] ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents
[LiteratureReference:3318393] ATF-2 contains a phosphorylation-dependent transcriptional activation domain
[LiteratureReference:450287] Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38
[LiteratureReference:450231] The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells
modified[InstanceEdit:4657005] Jupe, S, 2013-10-04
textATF2 (activating transcription factor 2) is a basic leucine zipper (bZIP) protein and member of the activator protein-1 (AP-1) family (Wagner et al. 2001). The basic region of ATF2 binds DNA while the leucine zipper region allows dimerization with partners. ATF2 is a histone acetyltransferase (HAT), which specifically acetylates histones H2B and H4 in vitro. ATF2 is sequentially phosphorylated on threonine residues T69 and T71 by protein kinases ERK1/2 and p38 (van Dam et al. 1995, Livingstone et al. 1995, Ouwens et al. 2002, Baan et al. 2009). This phosphorylated form has increased HAT activity (Kawasaki et al. 2000).
(summation)[Reaction:3318415] ATF2 acetylates histone H2B, H4 [Homo sapiens]
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