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Details on Person SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3

Class:IdFailedReaction:3311014
_displayNameSMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3
_doReleaseTRUE
_timestamp2018-05-10 15:25:21
authored[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08
[InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08
[InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
compartment[Compartment:70101] cytosol
created[InstanceEdit:3311015] Orlic-Milacic, M, 2013-04-24
disease[Disease:1500689] cancer
edited[InstanceEdit:3322153] Jassal, Bijay, 2013-05-03
[InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
entityFunctionalStatus[EntityFunctionalStatus:3311016] loss_of_function of SMAD4 MH2 domain mutants
input[DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens]
[DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens]
[CandidateSet:3311017] SMAD4 MH2 domain mutants [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:3318202] A structural basis for mutational inactivation of the tumour suppressor Smad4
[LiteratureReference:3304374] SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer
modified[InstanceEdit:3318654] Orlic-Milacic, M, 2013-04-29
[InstanceEdit:4224003] Orlic-Milacic, M, 2013-08-15
[InstanceEdit:4410468] Orlic-Milacic, M, 2013-08-23
[InstanceEdit:4542299] Orlic-Milacic, M, 2013-09-04
[InstanceEdit:4542300] Orlic-Milacic, M, 2013-09-04
[InstanceEdit:9608146] Orlic-Milacic, Marija, 2018-05-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameSMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3
normalReaction
releaseDate2013-09-18
reviewed[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08
[InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545289] R-HSA-3311014.3
summation[Summation:3318651] SMAD4 MH2 domain mutants are not able to form heterotrimers ...
(hasEvent)[Pathway:3311021] SMAD4 MH2 Domain Mutants in Cancer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777040] Update Tracker - [FailedReaction:3311014] SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 - v73:[modifyText]
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