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Details on Person KAT2A (GCN5) and KAT2B (PCAF) are histone acetyltransferases...
| Class:Id | Summation:3301302 |
|---|---|
| _displayName | KAT2A (GCN5) and KAT2B (PCAF) are histone acetyltransferases... |
| _timestamp | 2013-10-04 10:34:24 |
| created | [InstanceEdit:3301358] Jupe, S, 2013-04-22 |
| literatureReference | [LiteratureReference:3662261] The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes [LiteratureReference:3301293] The double-histone-acetyltransferase complex ATAC is essential for mammalian development [LiteratureReference:3301262] Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction [LiteratureReference:3322938] Expanded lysine acetylation specificity of Gcn5 in native complexes [LiteratureReference:4549230] Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines [LiteratureReference:4549235] Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3 [LiteratureReference:3662278] The Drosophila histone acetyltransferase Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation [LiteratureReference:3301368] ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding [LiteratureReference:3662244] Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein [LiteratureReference:3662235] The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes [LiteratureReference:3662299] ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes [LiteratureReference:3662315] ATAC-king the complexity of SAGA during evolution [LiteratureReference:3301251] Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo [LiteratureReference:3662238] Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation [LiteratureReference:3662262] A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing |
| modified | [InstanceEdit:3301915] Jupe, S, 2013-04-23 [InstanceEdit:3322952] Jupe, S, 2013-05-07 [InstanceEdit:3656497] Jupe, S, 2013-06-05 [InstanceEdit:3662243] Jupe, S, 2013-06-06 [InstanceEdit:3662332] Jupe, S, 2013-06-07 [InstanceEdit:4549218] Jupe, S, 2013-09-11 [InstanceEdit:4657005] Jupe, S, 2013-10-04 |
| text | KAT2A (GCN5) and KAT2B (PCAF) are histone acetyltransferases (HATs) that act as part of large multimember complexes to facilitate transcription by acetylating histones H3 and H4. In eukaryotes the SPT-ADA-GCN5 acetyltransferase (SAGA) complex has 19 subunits including TRRAP, ENY2, USP22 and subunits belonging to the ADA, SPT, TAF, and SGF group of proteins (Nagy et al. 2009). The ADA2A-containing (ATAC) complex shares with SAGA a core composed of KAT2A-TADA3 (ADA3)-CCDC101 (STAF36, SGF29) and either TADA2A (ADA2a) in ATAC, or TADA2B (ADA2b) in SAGA. ATAC complexes contain a second putative HAT, called CSRP2BP (ATAC2), and five other subunits; YEATS2, ZZZ3, MBIP, WDR5, and DR1 (NC2-Beta) (Guelman et al. 2009). CSRP2BP has weak HAT activity in vitro but it's main function is to maintain the structural integrity of ATAC (Guelman et al. 2009). At present, the biological function of the ATAC complex is not well understood. In vitro GCN5 acetylates mainly histone H3K14 (lysine-15 in the UniProt peptide which retains the initiating methionine), but when incorporated into the SAGA complex GCN5 becomes more efficient as an H3K14 acetylase and can also acetylate H3K9 and H3K18 (Brand et al. 1999, Grant et al. 1999), H3K23, and H3K27 (Kuo et al. 1996, Kuo & Andrews 2013). Drosophila ATAC mainly acetylates histone H4 (Ciurciu et al. 2006, Suganuma et al. 2008), suggested to be due to the presence of CSRP2BP in the complex (Suganuma et al. 2008) but different human ATAC preparations have exhibited a range of specificities with no clear difference between SAGA and ATAC (Guelman et al. 2009, Wang et al. 2008, Nagy et al. 2010). SAGA and ATAC complexes from mouse and human contain either GCN5 or PCAF in a mutually exclusive manner (Nagy et al. 2010, Krebs et al. 2010, Spedale et al. 2012). The SAGA complex consists of KAT2A (hGCN5), TADA1 (STAF42), TADA2B (ADA2b), TADA3 (STAF54, ADA3), SUPT3H (SPT3), SUPT7L (STAF65G), TAF5L (PAF65B), TAF6L (PAF65A), TAF9 (TAFII31), TAF12 (TAFII20), TAF10 (TAFII31), TRRAP, SAP130 (Martinez et al. 2001), CCDC101, ATXN7, a factor termed STAF55 that cannot be identified, two further factors described as probable members that cannot be identified STAF46 and STAF60 (Nagy & Tora 2007) plus ATXN7L3, USP22, ENY2 (Zhao et al. 2008) and SUPT20H (Nagy et al. 2009). N.B. Coordinates of post-translational modifications described here follow UniProt standard practice whereby coordinates refer to the translated protein before any further processing. Histone literature typically refers to coordinates of the protein after the initiating methionine has been removed. Therefore the coordinates of post-translated residues in the Reactome database and described here are frequently +1 when compared with the literature. |
| (summation) | [Reaction:3301237] KAT2 complexes acetylate histone H3 [Homo sapiens] |
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No pathways have been reviewed or authored by KAT2A (GCN5) and KAT2B (PCAF) are histone acetyltransferases... (3301302)
