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Details on Person CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1

Class:Id	Reaction:3299753
_displayName	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1
_doRelease	TRUE
_timestamp	2018-01-20 10:28:03
authored	[InstanceEdit:3299684] May, B, 2013-04-20
catalystActivity	[CatalystActivity:3299709] superoxide dismutase copper chaperone activity of CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3299742] May, B, 2013-04-20
edited	[InstanceEdit:3299684] May, B, 2013-04-20
input	[Complex:3299706] CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] [Homo sapiens] [Complex:3299706] CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:3299723] Human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) [LiteratureReference:3299724] The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase [LiteratureReference:3299740] The copper chaperone for superoxide dismutase [LiteratureReference:3299746] Mechanism of Cu,Zn-superoxide dismutase activation by the human metallochaperone hCCS [LiteratureReference:3299710] Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase [LiteratureReference:3299738] The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase [LiteratureReference:3299735] Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria [LiteratureReference:3343746] Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS
modified	[InstanceEdit:3343748] May, B, 2013-05-12 [InstanceEdit:3697905] May, B, 2013-06-09 [InstanceEdit:3780990] May, B, 2013-06-27 [InstanceEdit:4415003] May, B, 2013-08-23 [InstanceEdit:4420243] May, B, 2013-08-31 [InstanceEdit:4837349] May, B, 2013-11-01 [InstanceEdit:9029487] May, Bruce, 2017-11-20 [InstanceEdit:9035261] May, Bruce, 2018-01-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1
output	[Complex:3299679] 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] [Homo sapiens] [Complex:3299731] CCS:Zn2+:Cu1+ dimer [cytosol] [Homo sapiens]
precedingEvent	[Reaction:8951723] 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates [Homo sapiens] [Reaction:3697860] SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ [Homo sapiens]
releaseDate	2013-12-04
reviewed	[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644750] R-HSA-3299753.3
summation	[Summation:3343709] Copper chaperone of superoxide dismutase (CCS) transfers a c...
(hasEvent)	[Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens]
(inferredFrom)	[Reaction:3780979] CCS transfers Cu to SOD1 (mitochondrial) [Homo sapiens]
(precedingEvent)	[Reaction:3299691] SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) [Homo sapiens]
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No pathways have been reviewed or authored by CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (3299753)