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Details on Person HCAR3 (GPR109B) is activated by 3-hydroxyoctanoic acid (3HO)...

Class:IdSummation:3296283
_displayNameHCAR3 (GPR109B) is activated by 3-hydroxyoctanoic acid (3HO)...
_timestamp2013-04-18 12:10:27
created[InstanceEdit:3296264] Jupe, S, 2013-04-18
literatureReference[LiteratureReference:3296307] Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis
[LiteratureReference:444673] Molecular identification of high and low affinity receptors for nicotinic acid
[LiteratureReference:3296208] Simultaneous analysis of plasma free fatty acids and their 3-hydroxy analogs in fatty acid beta-oxidation disorders
[LiteratureReference:3296241] Addition of quantitative 3-hydroxy-octadecanoic acid to the stable isotope gas chromatography-mass spectrometry method for measuring 3-hydroxy fatty acids
modified[InstanceEdit:3296337] Jupe, S, 2013-04-18
textHCAR3 (GPR109B) is activated by 3-hydroxyoctanoic acid (3HO) (Ahmed et al. 2009) and nicotinic acid (niacin) (Wise et al. 2003). 3HO is an intermediate of fatty acid beta-oxidation. Under conditions of increased beta-oxidation flux, such as during starvation, under a ketogenic diet, or in patients with diabetic ketoacidosis, 3HO plasma concentrations are sufficient to activate the HCAR3 receptor (Costa et al. 1998, Jones et al. 2002, Ahmed et al. 2009).
(summation)[Reaction:3296309] HCAR3 binds HCAR3 ligands [Homo sapiens]
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