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Details on Person Defective G6PC does not hydrolyze glucose 6-phosphate

Class:IdFailedReaction:3274540
_displayNameDefective G6PC does not hydrolyze glucose 6-phosphate
_doReleaseTRUE
_timestamp2015-09-04 20:49:27
authored[InstanceEdit:3907318] D'Eustachio, P, 2013-07-19
catalystActivity[CatalystActivity:9631870] glucose-6-phosphatase activity of G6PC mutants [endoplasmic reticulum membrane]
compartment[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:3274539] D'Eustachio, P, 2013-04-11
disease[Disease:3229120] glycogen storage disease I
edited[InstanceEdit:6791027] D'Eustachio, Peter, 2015-08-17
entityFunctionalStatus[EntityFunctionalStatus:3274536] loss_of_function of G6PC mutants [endoplasmic reticulum membrane]
input[SimpleEntity:113782] G6P [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
isChimericFALSE
literatureReference[LiteratureReference:3274528] Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a
[LiteratureReference:3274546] Mutations in the glucose-6-phosphatase-alpha (G6PC) gene that cause type Ia glycogen storage disease
modified[InstanceEdit:3274557] D'Eustachio, P, 2013-04-11
[InstanceEdit:3907319] D'Eustachio, P, 2013-07-19
[InstanceEdit:4006040] D'Eustachio, P, 2013-07-25
[InstanceEdit:5096336] D'Eustachio, P, 2013-11-08
[InstanceEdit:5146702] D'Eustachio, P, 2013-11-18
[InstanceEdit:5357595] D'Eustachio, Peter, 2014-03-24
[InstanceEdit:6791025] D'Eustachio, Peter, 2015-08-17
[InstanceEdit:9631717] Wu, G, 2018-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameDefective G6PC does not hydrolyze glucose 6-phosphate
normalReaction
releaseDate2015-09-22
releaseStatusNEW
reviewed[InstanceEdit:6791026] Jassal, Bijay, 2015-08-17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:6797115] R-HSA-3274540.3
summation[Summation:3274549] Glucose-6-phosphatase (G6PC) associated with the inner face ...
(hasEvent)[Pathway:3274531] Glycogen storage disease type Ia (G6PC) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778230] Update Tracker - [FailedReaction:3274540] Defective G6PC does not hydrolyze glucose 6-phosphate - v68:[addCatalystActivity]
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