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| Class:Id | Summation:3270618 |
|---|---|
| _displayName | TANK-binding kinase 1 (TBK1) and interferon regulatory facto... |
| _timestamp | 2013-04-11 15:37:50 |
| created | [InstanceEdit:3270620] Shamovsky, V, 2013-04-11 |
| literatureReference | [LiteratureReference:165917] The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection [LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:933497] Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases [LiteratureReference:933507] SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways [LiteratureReference:2396006] STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway |
| text | TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with distinct scaffolding proteins that appeared to target TBK1 to different subcellular compartments [Hemmi H et al 2004; Oganesyan G et al 2006; Chariot A et al 2002; Huang J et al 2005]. STING interacted with both TBK1 and IRF3. Once STING is stimulated, its C-terminus served as a signaling scaffold to recruit IRF3 anhd TBK1, which led to TBK1-dependent phosphorylation of IRF3. Phosphorylation of IRF3 promoted its dimerization and translocation to the nucleus, where it triggered the transcription of interferon stimulated genes (ISGs) (Tanaka Y and Chen ZJ 2012). |
| (summation) | [Pathway:3270619] IRF3-mediated induction of type I IFN [Homo sapiens] |
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