Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person polySUMO2,3-K391,K477-HIF1A [nucleoplasm]

Class:IdEntityWithAccessionedSequence:3261200
_displayNamepolySUMO2,3-K391,K477-HIF1A [nucleoplasm]
_timestamp2022-01-18 18:49:24
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:3261182] May, B, 2013-04-10
endCoordinate826
hasModifiedResidue[GroupModifiedResidue:3261189] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 391
[GroupModifiedResidue:3261192] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 477
literatureReference[LiteratureReference:3261126] Sumoylation increases HIF-1alpha stability and its transcriptional activity
[LiteratureReference:3261123] SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity
[LiteratureReference:5627513] Proteome-wide identification of SUMO2 modification sites
modified[InstanceEdit:3632837] May, B, 2013-05-26
[InstanceEdit:3730756] May, B, 2013-06-15
[InstanceEdit:3899313] May, B, 2013-07-12
[InstanceEdit:4006039] May, B, 2013-07-24
[InstanceEdit:5627522] May, Bruce, 2014-10-19
[InstanceEdit:6804486] May, Bruce, 2015-10-11
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:9762188] May, Bruce, 2022-01-18
namepolySUMO2,3-K391,K477-HIF1A
SUMO2,3 N-glycyl-lys391,477 HIF1A
Hypoxia-inducible factor 1-alpha
HIF1A_HUMAN
referenceEntity[ReferenceGeneProduct:56516] UniProt:Q16665 HIF1A [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8929976] R-HSA-3261200.1
startCoordinate1
(output)[Reaction:3296174] RANBP2 SUMOylates HIF1A with SUMO2,3 [Homo sapiens]
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No pathways have been reviewed or authored by polySUMO2,3-K391,K477-HIF1A [nucleoplasm] (3261200)