Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Negative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]'

Class:IdNegativeRegulation:3249388
_displayNameNegative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]'
_timestamp2018-05-08 20:36:36
created[InstanceEdit:3249381] Shamovsky, V, 2013-04-09
modified[InstanceEdit:3465582] Shamovsky, V, 2013-05-17
[InstanceEdit:8948714] Shamovsky, Veronica, 2016-11-15
[InstanceEdit:9608020] Wu, G, 2018-05-08
regulator[Complex:8948707] NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] [Homo sapiens]
stableIdentifier[StableIdentifier:3656195] R-HSA-3249388.2
(regulatedBy)[Reaction:2396007] IRF3 is phosphorylated by TBK1 [Homo sapiens]
(regulation)[RegulationReference:9641919] Negative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]' NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
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No pathways have been reviewed or authored by Negative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]' (3249388)