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Details on Person NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
| Class:Id | LiteratureReference:3249374 |
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| _displayName | NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4 |
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| _timestamp | 2013-04-09 05:48:09 |
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| author | [Person:3249368] Cui, Jun
[Person:3249380] Li, Yinyin
[Person:3249377] Zhu, Liang
[Person:418118] Liu, D
[Person:418112] Songyang, Z
[Person:3249389] Wang, Helen Y
[Person:3249394] Wang, Rong-Fu |
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| created | [InstanceEdit:3249381] Shamovsky, V, 2013-04-09 |
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| journal | Nat. Immunol. |
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| pages | 387-95 |
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| pubMedIdentifier | 22388039 |
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| title | NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4 |
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| volume | 13 |
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| year | 2012 |
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| (literatureReference) | [Complex:3249384] NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] [Homo sapiens]
[Complex:8948707] NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] [Homo sapiens]
[Reaction:3249386] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 [Homo sapiens]
[Reaction:3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 [Homo sapiens]
[Reaction:8948703] NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 [Homo sapiens]
[Reaction:8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 [Homo sapiens]
[Summation:3249382] NLRP4 (or NACHT, LRR and PYD domains-containing protein 4) a...
[RegulationReference:9641587] Negative regulation by 'NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]' NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
[RegulationReference:9641919] Negative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]' NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4 |
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