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Details on Person TBK1 phosphorylates STAT6 at Ser407

Class:Id	Reaction:3249371
_displayName	TBK1 phosphorylates STAT6 at Ser407
_doRelease	TRUE
_timestamp	2013-05-31 09:48:41
authored	[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
catalystActivity	[CatalystActivity:3249393] protein serine/threonine kinase activity of STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane]
compartment	[Compartment:70101] cytosol [Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:3249381] Shamovsky, V, 2013-04-09
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:3249391] STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3249356] Activation of STAT6 by STING is critical for antiviral innate immunity
modified	[InstanceEdit:3261243] Shamovsky, V, 2013-04-10 [InstanceEdit:3465584] Shamovsky, V, 2013-05-17 [InstanceEdit:3465600] Shamovsky, V, 2013-05-17 [InstanceEdit:3465604] Shamovsky, V, 2013-05-17 [InstanceEdit:3597629] Shamovsky, V, 2013-05-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TBK1 phosphorylates STAT6 at Ser407
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:2396005] STING:p-S172-TBK1 [cytoplasmic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:3249369] p-S407-STAT6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3249369] p-S407-STAT6 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:3249390] TBK1 is phosphorylated within STING:TBK1:STAT6 complex [Homo sapiens] [Reaction:3249378] STING recruits TBK1 and STAT6 [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654499] R-HSA-3249371.2
summation	[Summation:3261229] Upon viral infection STAT6 undergoes Ser407 phosphorylation,...
(hasEvent)	[Pathway:3249367] STAT6-mediated induction of chemokines [Homo sapiens]
(precedingEvent)	[Reaction:3249379] p-S407-STAT6 is phosphorylated at Tyr641 [Homo sapiens]
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No pathways have been reviewed or authored by TBK1 phosphorylates STAT6 at Ser407 (3249371)