Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person STING dimerization is essential for the induction of IFN res...

Class:IdSummation:3249348
_displayNameSTING dimerization is essential for the induction of IFN res...
_timestamp2021-01-27 01:40:24
created[InstanceEdit:3249349] Shamovsky, V, 2013-04-08
literatureReference[LiteratureReference:2408415] ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
[LiteratureReference:2396011] STING is a direct innate immune sensor of cyclic di-GMP
[LiteratureReference:2453941] MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP
[LiteratureReference:2395975] Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
[LiteratureReference:2453922] Cellular reactive oxygen species inhibit MPYS induction of IFN?
[LiteratureReference:9711012] SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex
modified[InstanceEdit:3249401] Shamovsky, V, 2013-04-09
[InstanceEdit:3270621] Shamovsky, V, 2013-04-11
[InstanceEdit:9711030] Shamovsky, Veronica, 2021-01-07
[InstanceEdit:9713615] Shamovsky, Veronica, 2021-01-27
textSTING dimerization is essential for the induction of IFN response (Sun W et al. 2009; Burdette DL et al. 2011; Jin L et al. 2011; Ouyang S et al. 2012). Mouse Sting/Myps has been also reported to exist as a dimer constitutively [Jin L et al 2008]. Moreover, STING can function as a ROS sensor, which forms a disulfide‑linked homodimer under conditions of oxidative stress in HEK293T cells (Jin L et al 2010). Structural studies revealed that the strictly conserved cytosolic aa 153‑173 region of STING participates in dimerization via hydrophobic interactions (Ouyang S et al. 2012).

STING was shown to undergo K63‑linked ubiquitination, which may facilitate its dimerization (Tsuchid T et al. 2010; Zhang J et al. 2012). The de‑ubiquitinating enzyme, severe acute respiratory syndrome coronavirus type 1 (SARS‑CoV-1) 1a‑encoded papain‑like protease (PLPro or nsp3), inhibits the ubiquitination of STING (Chen X et al. 2014).

(summation)[Reaction:3134800] STING dimerization [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by STING dimerization is essential for the induction of IFN res... (3249348)
Follow Reactome