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Details on Person Direct binding assays with radiolabeled substrate showed tha...
| Class:Id | Summation:3249345 |
|---|---|
| _displayName | Direct binding assays with radiolabeled substrate showed tha... |
| _timestamp | 2013-05-20 09:37:14 |
| created | [InstanceEdit:3249349] Shamovsky, V, 2013-04-08 |
| literatureReference | [LiteratureReference:3244591] Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA [LiteratureReference:2408399] Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING [LiteratureReference:3508887] Cyclic [G(2',5')pA(3',5')p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase |
| modified | [InstanceEdit:3249401] Shamovsky, V, 2013-04-09 [InstanceEdit:3270621] Shamovsky, V, 2013-04-11 [InstanceEdit:3301374] Shamovsky, V, 2013-04-22 [InstanceEdit:3508920] Shamovsky, V, 2013-05-20 |
| text | Direct binding assays with radiolabeled substrate showed that the association of STING protein (residues 139-379) with [32P]-cGAMP was inhibited in the presence of competing cold cGAMP, c-di-GMP or c-di-AMP, suggesting that the cGAMP binding sites on STING might overlap with those that interact with c-di-GMP and c-di-AMP (Wu J et al.2013). Indeed, mutations of several residues that were shown to participate in the binding of STING to c-di-GMP, including S161Y, Y240S and N242A, also impaired the binding of STING to cGAMP (Yin Q et al. 2012; Wu J et al.2013). Structural study revealed that cGAMP generated by cGAS contains G(2',5')pA and A(3',5')pG phosphodiester linkages, which is distinct from bacterial 3',5' cyclic dinucleotides (Gao P et al. 2013). |
| (summation) | [BlackBoxEvent:3244643] STING binds cyclic GMP-AMP [Homo sapiens] |
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