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Details on Person secretion of WNT ligands

Class:IdReaction:3247843
_displayNamesecretion of WNT ligands
_doReleaseTRUE
_timestamp2013-05-31 09:44:54
authored[InstanceEdit:3247883] Rothfels, K, 2013-04-05
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:3247846] Rothfels, K, 2013-04-05
edited[InstanceEdit:3451017] Matthews, L, 2013-04-12
input[Complex:3247838] WLS:WNT [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3247723] WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification
[LiteratureReference:3247721] Wnt trafficking: new insights into Wnt maturation, secretion and spreading
[LiteratureReference:3247699] Release and trafficking of lipid-linked morphogens
modified[InstanceEdit:3451033] Rothfels, K, 2013-05-16
[InstanceEdit:3621897] Rothfels, K, 2013-05-24
[InstanceEdit:3632861] Rothfels, K, 2013-05-27
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namesecretion of WNT ligands
output[EntityWithAccessionedSequence:3247746] WLS [plasma membrane] [Homo sapiens]
[DefinedSet:3247835] WNTs [extracellular region] [Homo sapiens]
precedingEvent
releaseDate2013-06-11
reviewed[InstanceEdit:3621851] Boutros, Michael, 2013-05-24
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3654410] R-HSA-3247843.2
summation[Summation:3247765] Vacuolar acidification is required but not sufficient for th...
(hasEvent)[Pathway:3238698] WNT ligand biogenesis and trafficking [Homo sapiens]
(precedingEvent)[Reaction:1458875] WNT binds to FZD and LRP5/6 [Homo sapiens]
[BlackBoxEvent:3247847] WLS is endocytosed to the early endosome [Homo sapiens]
[Reaction:3769370] WIF1 binds WNTs [Homo sapiens]
[Reaction:3772441] sFRP binds WNT3A and inhibits WNT:FZD binding [Homo sapiens]
[Reaction:3858491] WNTs bind the FZD receptor to initiate PCP pathway [Homo sapiens]
[Reaction:3965446] WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling [Homo sapiens]
[Reaction:4551555] RYK binds WNT5A and VANGL2 [Homo sapiens]
[Reaction:4551571] WNT5A binds ROR2 and VANGL2 [Homo sapiens]
[Reaction:5099886] WNT5A binding to FZD promotes PRICKLE1 degradation [Homo sapiens]
[Reaction:5099899] WNT5A binds FZD4 [Homo sapiens]
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No pathways have been reviewed or authored by secretion of WNT ligands (3247843)