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Details on Person PIAS1 SUMOylates SP3 with SUMO1 at lysine-551 (Ross et al. 2...

Class:IdSummation:3247498
_displayNamePIAS1 SUMOylates SP3 with SUMO1 at lysine-551 (Ross et al. 2...
_timestamp2015-10-10 10:27:30
created[InstanceEdit:3247468] May, B, 2013-04-04
modified[InstanceEdit:5682567] May, Bruce, 2015-03-09
[InstanceEdit:6804473] May, Bruce, 2015-10-10
textPIAS1 SUMOylates SP3 with SUMO1 at lysine-551 (Ross et al. 2002, Sapetschnig et al. 2002, Sapetschnig et al. 2004, Spengler et al. 2005, Ellis et al. 2006, Impens et al. 2014). A minor amount of SUMOylation is also observed at lysine-120 (Ross et al. 2002). The effects of SUMOylation on the activities of isoforms of SP3 are promoter-dependent (Sapetschnig et al. 2004). Generally SUMOylation reduces the transcription activation capacity of the long and the short isoforms of Sp3 (Ross et al. 2002, Sapetschnig et al 2004, Ellis et al 2006). Mechanistically, SUMO attachment to Sp3 serves as a molecular beacon for the recruitment of chromatin-modifying machineries that impose epigenetic silencing (inferred from Drosophila homologs in Stielow et al. 2008a, inferred from mouse homologs in Stielow et al. 2008b).
(summation)[Reaction:3247493] PIAS1 SUMOylates SP3 with SUMO1 [Homo sapiens]
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