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Details on Person PIAS1 SUMOylates SP3 with SUMO1

Class:Id	Reaction:3247493
_displayName	PIAS1 SUMOylates SP3 with SUMO1
_doRelease	TRUE
_timestamp	2022-01-19 16:39:15
authored	[InstanceEdit:3246138] May, B, 2013-03-30
catalystActivity	[CatalystActivity:3247478] SUMO transferase activity of PIAS1 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643901] SUMO transferase activity of PIAS1 [nucleoplasm] Transcription factor Sp3 is silenced through SUMO modification by PIAS1
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3247468] May, B, 2013-04-04
edited	[InstanceEdit:3246138] May, B, 2013-03-30
goBiologicalProcess	[GO_BiologicalProcess:4162] protein sumoylation
input	[EntityWithAccessionedSequence:2160951] SP3 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3247421] Transcription factor Sp3 is silenced through SUMO modification by PIAS1 [LiteratureReference:3247479] SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization [LiteratureReference:3247446] Complexity of translationally controlled transcription factor Sp3 isoform expression [LiteratureReference:3247473] Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism [LiteratureReference:3247477] The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter [LiteratureReference:5626900] Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli [LiteratureReference:6804461] SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing [LiteratureReference:6804464] Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen
modified	[InstanceEdit:3730661] May, B, 2013-06-14 [InstanceEdit:5626908] May, Bruce, 2014-10-13 [InstanceEdit:6804473] May, Bruce, 2015-10-10 [InstanceEdit:8865030] D'Eustachio, Peter, 2016-03-18 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9762281] May, Bruce, 2022-01-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS1 SUMOylates SP3 with SUMO1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3247472] monoSUMO1-K551-SP3 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6804460] Suske, Guntram, 2015-10-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812330] R-HSA-3247493.5
summation	[Summation:3247498] PIAS1 SUMOylates SP3 with SUMO1 at lysine-551 (Ross et al. 2...
(hasEvent)	[Pathway:3232118] SUMOylation of transcription factors [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774861] Update Tracker - [Reaction:3247493] PIAS1 SUMOylates SP3 with SUMO1 - v80:[add_removeOutput]
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No pathways have been reviewed or authored by PIAS1 SUMOylates SP3 with SUMO1 (3247493)