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Details on Person STING binds cyclic GMP-AMP

Class:Id	BlackBoxEvent:3244643
_displayName	STING binds cyclic GMP-AMP
_doRelease	TRUE
_timestamp	2013-05-31 09:45:02
authored	[InstanceEdit:2396013] Shamovsky, V, 2012-07-09
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
input	[Complex:2395989] STING:STING [endoplasmic reticulum membrane] [Homo sapiens] [SimpleEntity:3244587] c-GMP-AMP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:3244591] Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA [LiteratureReference:3244594] Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
modified	[InstanceEdit:3248025] Shamovsky, V, 2013-04-05 [InstanceEdit:3249352] Shamovsky, V, 2013-04-08 [InstanceEdit:3301848] Shamovsky, V, 2013-04-22 [InstanceEdit:3465584] Shamovsky, V, 2013-05-17 [InstanceEdit:3465600] Shamovsky, V, 2013-05-17 [InstanceEdit:3465604] Shamovsky, V, 2013-05-17 [InstanceEdit:3597629] Shamovsky, V, 2013-05-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	STING binds cyclic GMP-AMP
output	[Complex:3244600] STING:cGAMP [cytoplasmic vesicle membrane] [Homo sapiens]
precedingEvent	[Reaction:3134800] STING dimerization [Homo sapiens] [BlackBoxEvent:9711016] SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING [Homo sapiens] [Reaction:3134804] STING ubiquitination by TRIM32 or TRIM56 [Homo sapiens] [Reaction:3244614] cGAS produces cyclic GMP-AMP [Homo sapiens] [Reaction:3244647] cGAS binds cytosolic DNA [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654412] R-HSA-3244643.2
summation	[Summation:3249345] Direct binding assays with radiolabeled substrate showed tha...
(hasEvent)	[Pathway:1834941] STING mediated induction of host immune responses [Homo sapiens]
(precedingEvent)	[Reaction:1834939] STING recruits TBK1 and IRF3 [Homo sapiens]
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No pathways have been reviewed or authored by STING binds cyclic GMP-AMP (3244643)