Query author contributions in Reactome

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Details on Person Hollis, Thomas

Class:Id	Person:3244615
_displayName	Hollis, Thomas
_timestamp	2013-03-28 05:14:38
created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
firstname	Thomas
initial	T
surname	Hollis
(author)	[LiteratureReference:3244662] The TREX1 exonuclease R114H mutation in Aicardi-Gouti�res syndrome and lupus reveals dimeric structure requirements for DNA degradation activity [LiteratureReference:3247886] The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering [LiteratureReference:3247919] Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome [LiteratureReference:3247939] Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus [LiteratureReference:3247960] Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease [LiteratureReference:3247963] The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis [LiteratureReference:3247970] The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease [LiteratureReference:3247972] DNA binding induces active site conformational change in the human TREX2 3'-exonuclease [LiteratureReference:3248000] Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome [LiteratureReference:8866603] Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
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No pathways have been reviewed or authored by Hollis, Thomas (3244615)