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Details on Person cGAS produces cyclic GMP-AMP

Class:IdReaction:3244614
_displayNamecGAS produces cyclic GMP-AMP
_doReleaseTRUE
_timestamp2018-11-08 00:33:24
authored[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
catalystActivity[CatalystActivity:3244649] 2',3'-cyclic GMP-AMP synthase activity of cGAS:dsDNA [cytosol]
catalystActivityReference[CatalystActivityReference:9643596] cyclic-GMP-AMP synthase activity of cGAS:dsDNA [cytosol] Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
compartment[Compartment:70101] cytosol
created[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
edited[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29438] GTP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:3244591] Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
[LiteratureReference:3244594] Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
modified[InstanceEdit:3248025] Shamovsky, V, 2013-04-05
[InstanceEdit:3249352] Shamovsky, V, 2013-04-08
[InstanceEdit:3465584] Shamovsky, V, 2013-05-17
[InstanceEdit:3465600] Shamovsky, V, 2013-05-17
[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
[InstanceEdit:3597629] Shamovsky, V, 2013-05-21
[InstanceEdit:9628338] Shamovsky, Veronica, 2018-11-08
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namecGAS produces cyclic GMP-AMP
output[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:3244587] c-GMP-AMP [cytosol]
precedingEvent
relatedSpecies[Species:5689680] Human herpesvirus 1
[Species:164493] Human immunodeficiency virus 1
[Species:8875362] Listeria monocytogenes
[Species:176806] Mycobacterium tuberculosis
releaseDate2013-06-11
reviewed[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11
[InstanceEdit:3597627] Jin, Lei, 2013-05-21
[InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3654323] R-HSA-3244614.4
summation[Summation:3249351] Cyclic dinucleotides (such as c-di-GMP and c-di-AMP) are sig...
(hasEvent)[Pathway:1834941] STING mediated induction of host immune responses [Homo sapiens]
(precedingEvent)[BlackBoxEvent:3244643] STING binds cyclic GMP-AMP [Homo sapiens]
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No pathways have been reviewed or authored by cGAS produces cyclic GMP-AMP (3244614)