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Details on Person PORCN palmitoleoylates N-glycosyl WNTs

Class:Id	Reaction:3238694
_displayName	PORCN palmitoleoylates N-glycosyl WNTs
_doRelease	TRUE
_timestamp	2013-05-31 09:40:50
authored	[InstanceEdit:3247883] Rothfels, K, 2013-04-05
catalystActivity	[CatalystActivity:3238207] acyltransferase activity, transferring groups other than amino-acyl groups of PORCN [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:3238693] Rothfels, K, 2013-03-27
edited	[InstanceEdit:3451017] Matthews, L, 2013-04-12
inferredFrom	[Reaction:3238687] PORCN palmitoleoylates WNT3a [Mus musculus]
input	[SimpleEntity:3238096] palmitoleoyl-CoA [endoplasmic reticulum lumen] [CandidateSet:3238268] N-glycosylated WNTs [endoplasmic reticulum lumen] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases [LiteratureReference:3238093] Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion [LiteratureReference:3238086] Structural basis of Wnt recognition by Frizzled [LiteratureReference:3238083] Glycosylation and palmitoylation of Wnt-3a are coupled to produce an active form of Wnt-3a [LiteratureReference:3238084] The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing [LiteratureReference:3238090] Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein [LiteratureReference:3238075] A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling [LiteratureReference:3238087] Wnt proteins are lipid-modified and can act as stem cell growth factors [LiteratureReference:3238078] A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities [LiteratureReference:3247701] Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome [LiteratureReference:3247725] Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos [LiteratureReference:3247704] Precise regulation of porcupine activity is required for physiological Wnt signaling [LiteratureReference:3247710] Porcupine-mediated lipidation is required for Wnt recognition by Wls [LiteratureReference:3247729] Lipid-independent secretion of a Drosophila Wnt protein [LiteratureReference:3289763] Differential palmit(e)oylation of Wnt1 on C93 and S224 residues has overlapping and distinct consequences
modified	[InstanceEdit:3247870] Rothfels, K, 2013-04-05 [InstanceEdit:3289770] Rothfels, K, 2013-04-15 [InstanceEdit:3451019] Rothfels, K, 2013-05-16 [InstanceEdit:3451188] Rothfels, K, 2013-05-16 [InstanceEdit:3621881] Rothfels, K, 2013-05-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PORCN palmitoleoylates N-glycosyl WNTs
output	[SimpleEntity:162743] CoA-SH [endoplasmic reticulum lumen] [CandidateSet:3238374] palmitoleyl-N-glycosylated WNTs [endoplasmic reticulum lumen] [Homo sapiens]
precedingEvent	[BlackBoxEvent:3238691] N-linked glycosylation of WNTs [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3621851] Boutros, Michael, 2013-05-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654301] R-HSA-3238694.2
summation	[Summation:3238689] All WNT proteins except Drosophila WntD are lipid modified. ...
(hasEvent)	[Pathway:3238698] WNT ligand biogenesis and trafficking [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:3247837] WNT ligands traffic to the Golgi [Homo sapiens]
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No pathways have been reviewed or authored by PORCN palmitoleoylates N-glycosyl WNTs (3238694)