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Details on Person PIAS4 SUMOylates CEBPA with SUMO1

Class:Id	Reaction:3232124
_displayName	PIAS4 SUMOylates CEBPA with SUMO1
_timestamp	2022-01-19 16:41:53
authored	[InstanceEdit:3222564] May, B, 2013-03-23
catalystActivity	[CatalystActivity:3215011] SUMO transferase activity of PIAS4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643693] SUMO transferase activity of PIAS4 [nucleoplasm] PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3232159] May, B, 2013-03-27
edited	[InstanceEdit:3222564] May, B, 2013-03-23
inferredFrom	[Reaction:3232133] Pias4 SUMOylates Cebpa with Sumo1 [Mus musculus]
input	[EntityWithAccessionedSequence:381289] CEBPA [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3232136] Differential effects of sumoylation on the activities of CCAAT enhancer binding protein alpha (C/EBP?) p42 versus p30 may contribute in part, to aberrant C/EBP? activity in acute leukemias [LiteratureReference:3232129] Target proteins of C/EBPalphap30 in AML: C/EBPalphap30 enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9
modified	[InstanceEdit:3730756] May, B, 2013-06-15 [InstanceEdit:4663810] May, B, 2013-10-06 [InstanceEdit:5626908] May, Bruce, 2014-10-13 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9762281] May, Bruce, 2022-01-19
name	PIAS4 SUMOylates CEBPA with SUMO1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3232144] monoSUMO1-K161-CEBPA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8903310] R-HSA-3232124.1
summation	[Summation:4663723] As inferred from mouse homologs, PIAS4 (PIASy) SUMOylates CE...
(hasEvent)	[Pathway:3232118] SUMOylation of transcription factors [Homo sapiens]
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No pathways have been reviewed or authored by PIAS4 SUMOylates CEBPA with SUMO1 (3232124)