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Details on Person MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)

Class:Id	Reaction:3229152
_displayName	MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)
_doRelease	TRUE
_timestamp	2013-09-05 11:48:12
authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:3228467] protein serine/threonine kinase activity of MAP3K5 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3229148] Orlic-Milacic, M, 2013-03-26
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
inferredFrom	[Reaction:3299417] MAP3K5 (ASK1) phosphorylates Map2k4(Sek1) [Homo sapiens]
input	[EntityWithAccessionedSequence:168107] MAP2K4 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:3228464] Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways [LiteratureReference:3229146] Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade
modified	[InstanceEdit:3299419] Orlic-Milacic, M, 2013-04-18 [InstanceEdit:3779452] Orlic-Milacic, M, 2013-06-27 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4420304] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4420306] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4542310] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)
output	[EntityWithAccessionedSequence:168170] p-S257,T261-MAP2K4 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:3225851] ROS oxidize thioredoxin and activate MAP3K5 [Homo sapiens] [BlackBoxEvent:3223236] RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545224] R-HSA-3229152.2
summation	[Summation:3299418] MAP3K5 (ASK1) phosphorylates and activates MAP2K4 (SEK1) (Ic...
(hasEvent)	[Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens]
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