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Details on Person MAP3K5 phosphorylates MKK3 and MKK6

Class:Id	Reaction:3228469
_displayName	MAP3K5 phosphorylates MKK3 and MKK6
_doRelease	TRUE
_timestamp	2013-09-05 11:42:16
authored	[InstanceEdit:3900006] Orlic-Milacic, M, 2013-07-15
catalystActivity	[CatalystActivity:3228467] protein serine/threonine kinase activity of MAP3K5 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3228463] Orlic-Milacic, M, 2013-03-25
edited	[InstanceEdit:3901124] D'Eustachio, P, 2013-07-15 [InstanceEdit:4542306] Matthews, L, 2013-07-15
input	[DefinedSet:167916] MAP2K3,MAP2K6 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:3228464] Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways [LiteratureReference:3228471] Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases
modified	[InstanceEdit:3296496] Orlic-Milacic, M, 2013-04-18 [InstanceEdit:3779452] Orlic-Milacic, M, 2013-06-27 [InstanceEdit:4415004] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4420304] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4420306] Orlic-Milacic, M, 2013-09-03 [InstanceEdit:4542310] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MAP3K5 phosphorylates MKK3 and MKK6
output	[DefinedSet:167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:3225851] ROS oxidize thioredoxin and activate MAP3K5 [Homo sapiens] [BlackBoxEvent:3223236] RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545108] R-HSA-3228469.2
summation	[Summation:3296494] MAP3K5 (ASK1) phosphorylates and activates MAP2K3 (MKK3) and...
(hasEvent)	[Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens]
(precedingEvent)	[Reaction:450296] Phosphorylated MKK3/MKK6 migrates to nucleus [Homo sapiens]
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No pathways have been reviewed or authored by MAP3K5 phosphorylates MKK3 and MKK6 (3228469)