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Details on Person BRD7 binds TP53 and EP300

Class:Id	Reaction:3222093
_displayName	BRD7 binds TP53 and EP300
_doRelease	TRUE
_timestamp	2017-02-23 16:21:40
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3222106] Orlic-Milacic, M, 2013-03-18
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:3222092] BRD7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [Complex:3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3222107] BRD7 is a candidate tumour suppressor gene required for p53 function [LiteratureReference:3222101] Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence [LiteratureReference:5628862] TIGAR, a p53-inducible regulator of glycolysis and apoptosis
modified	[InstanceEdit:5628839] Orlic-Milacic, Marija, 2014-10-23 [InstanceEdit:5628842] Orlic-Milacic, Marija, 2014-10-23 [InstanceEdit:5628845] Orlic-Milacic, Marija, 2014-10-23 [InstanceEdit:5628865] Orlic-Milacic, Marija, 2014-10-23 [InstanceEdit:6799118] Orlic-Milacic, Marija, 2015-09-21 [InstanceEdit:6804766] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:8856585] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8979254] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BRD7 binds TP53 and EP300
output	[Complex:3222096] BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:5684887] Activation of CHEK1 at resected DNA DSBs [Homo sapiens] [Reaction:264435] Dissociation of the COP1-p53 complex [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:176116] Recruitment and activation of Chk1 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:5683792] p-T68-CHEK2 autophosphorylates [Homo sapiens] [Reaction:264435] Dissociation of the COP1-p53 complex [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens] [Reaction:6805470] AMPK phosphorylates TP53 [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:6805479] TP53RK phosphorylates TP53 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861182] R-HSA-3222093.3
summation	[Summation:5628837] The N-terminal region of BRD7, upstream of its bromodomain t...
(hasEvent)	[Pathway:5628841] BRD7 Cooperates With TP53 in Transcription Control [Homo sapiens] [Pathway:6804758] Regulation of TP53 Activity through Acetylation [Homo sapiens]
(precedingEvent)	[Reaction:5628871] BRD7 promotes EP300-mediated acetylation of TP53 [Homo sapiens]
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No pathways have been reviewed or authored by BRD7 binds TP53 and EP300 (3222093)