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Details on Person Phosphorylation of WDR77 (MEP50) on threonine-5 by cyclin-de...
| Class:Id | Summation:3215429 |
|---|---|
| _displayName | Phosphorylation of WDR77 (MEP50) on threonine-5 by cyclin-de... |
| _timestamp | 2014-07-18 17:03:54 |
| created | [InstanceEdit:3215411] Jupe, S, 2013-03-15 |
| literatureReference | [LiteratureReference:3215459] Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase [LiteratureReference:5205605] Cycling to cancer with cyclin D1 [LiteratureReference:5205603] Location, location, location: the role of cyclin D1 nuclear localization in cancer [LiteratureReference:5205607] Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation |
| modified | [InstanceEdit:5205613] Jupe, S, 2013-12-04 [InstanceEdit:5211325] Jupe, S, 2013-12-09 [InstanceEdit:5609984] Jupe, Steve, 2014-07-18 |
| text | Phosphorylation of WDR77 (MEP50) on threonine-5 by cyclin-dependent kinase 4 (CDK4), as part of the complex cyclin D1: CDK4:PRMT5:WDR77 enhances PRMT5:WDR77 methyltransferase activity, which triggers events associated with cyclin D1-dependent neoplastic growth (Aggarwal et al. 2011). Cyclin D1 is an allosteric regulator of CDK4 and CDK6, mediating growth factor-dependent G1-phase progression. Growth factor stimulation induces cyclin D1 expression, its association with CDK4 and nuclear accumulation during mid-G1. Active cyclin D1:CDK4 catalyzes the phosphorylation-dependent inactivation of retinoblastoma (RB) family proteins (Diehl 2002, Gladden & Diehl 2005). Following the G1/S transition, cyclin D1 accumulation is opposed by phosphorylation of threonine-286 (T286) by glycogen synthase kinase 3 beta (GSK3beta), which promotes cyclin D1 nuclear export (Alt et al. 2000). |
| (summation) | [Reaction:3215385] CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 [Homo sapiens] |
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No pathways have been reviewed or authored by Phosphorylation of WDR77 (MEP50) on threonine-5 by cyclin-de... (3215429)
