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Details on Person TP53INP1 and HIPK2 bind TP53

Class:IdReaction:3215251
_displayNameTP53INP1 and HIPK2 bind TP53
_doReleaseTRUE
_timestamp2017-02-23 16:21:43
authored[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:3215248] Orlic-Milacic, M, 2013-03-15
edited[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input[EntityWithAccessionedSequence:3215226] TP53INP1 [nucleoplasm] [Homo sapiens]
[Complex:6799392] p-HIPK2:PIN1 [nucleoplasm] [Homo sapiens]
[Complex:3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3215228] TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity
[LiteratureReference:3215254] p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis
[LiteratureReference:6799386] HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation
[LiteratureReference:6799393] HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop
[LiteratureReference:6799379] Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death
modified[InstanceEdit:6799423] Orlic-Milacic, Marija, 2015-09-24
[InstanceEdit:6799426] Orlic-Milacic, Marija, 2015-09-24
[InstanceEdit:6799439] Orlic-Milacic, Marija, 2015-09-24
[InstanceEdit:6806021] Orlic-Milacic, Marija, 2015-10-21
[InstanceEdit:8856532] Orlic-Milacic, Marija, 2016-02-10
[InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10
[InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10
[InstanceEdit:8979254] Orlic-Milacic, Marija, 2017-02-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTP53INP1 and HIPK2 bind TP53
output[Complex:3215242] TP53INP1:p-HIPK2:PIN1:p-S15,S20-TP53 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8861190] R-HSA-3215251.3
summation[Summation:6799424] TP53INP1 (p53INP1) forms a complex with TP53 and its regulat...
(hasEvent)[Pathway:6804756] Regulation of TP53 Activity through Phosphorylation [Homo sapiens]
(precedingEvent)[Reaction:6799409] HIPK2 phosphorylates TP53 [Homo sapiens]
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No pathways have been reviewed or authored by TP53INP1 and HIPK2 bind TP53 (3215251)