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Details on Person TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter

Class:Id	Reaction:3215152
_displayName	TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter
_doRelease	TRUE
_timestamp	2017-02-23 16:21:43
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3215151] Orlic-Milacic, M, 2013-03-15
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:3215140] PRMT1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:400139] CARM1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3215141] GADD45A gene [nucleoplasm] [Homo sapiens] [Complex:3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3215145] Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53
modified	[InstanceEdit:6799324] Orlic-Milacic, Marija, 2015-09-23 [InstanceEdit:6803268] Orlic-Milacic, Marija, 2015-10-05 [InstanceEdit:6804121] Orlic-Milacic, Marija, 2015-10-08 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809236] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810438] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856096] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8979254] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter
output	[Complex:3215149] p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:5684887] Activation of CHEK1 at resected DNA DSBs [Homo sapiens] [Reaction:264435] Dissociation of the COP1-p53 complex [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:176116] Recruitment and activation of Chk1 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:5683792] p-T68-CHEK2 autophosphorylates [Homo sapiens] [Reaction:264435] Dissociation of the COP1-p53 complex [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens] [Reaction:6805470] AMPK phosphorylates TP53 [Homo sapiens] [Reaction:5693609] ATM phosphorylates TP53 at S15 [Homo sapiens] [Reaction:6799332] ATR phosphorylates TP53 [Homo sapiens] [Reaction:6805479] TP53RK phosphorylates TP53 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861192] R-HSA-3215152.3
summation	[Summation:6804119] TP53, together with chromatin modifying enzymes EP300, PRMT1...
(hasEvent)	[Pathway:6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest [Homo sapiens]
(normalReaction)	[FailedReaction:3701014] TP53 R175H does not bind GADD45A promoter [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:3215144] TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription [Homo sapiens]
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