Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Diagram of Oxidative Stress Induced Senescence, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, and Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
| Class:Id | PathwayDiagram:3214876 |
|---|---|
| _displayName | Diagram of Oxidative Stress Induced Senescence, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, and Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects |
| _timestamp | 2023-08-20 07:28:45 |
| created | [InstanceEdit:3214875] Orlic-Milacic, M, 2013-03-12 |
| height | 1553 |
| modified | [InstanceEdit:3225875] Orlic-Milacic, M, 2013-03-25 [InstanceEdit:3228462] Orlic-Milacic, M, 2013-03-25 [InstanceEdit:3228472] Orlic-Milacic, M, 2013-03-25 [InstanceEdit:3228473] Orlic-Milacic, M, 2013-03-25 [InstanceEdit:3229117] Orlic-Milacic, M, 2013-03-26 [InstanceEdit:3229141] Orlic-Milacic, M, 2013-03-26 [InstanceEdit:3229153] Orlic-Milacic, M, 2013-03-26 [InstanceEdit:3239025] Orlic-Milacic, M, 2013-03-27 [InstanceEdit:3239851] Orlic-Milacic, M, 2013-03-27 [InstanceEdit:3240299] Orlic-Milacic, M, 2013-03-27 [InstanceEdit:3240959] Orlic-Milacic, M, 2013-03-27 [InstanceEdit:3296496] Orlic-Milacic, M, 2013-04-18 [InstanceEdit:3297952] Orlic-Milacic, M, 2013-04-18 [InstanceEdit:3463841] Orlic-Milacic, M, 2013-05-16 [InstanceEdit:3772115] Orlic-Milacic, M, 2013-06-24 [InstanceEdit:3772133] Orlic-Milacic, M, 2013-06-24 [InstanceEdit:3777188] Orlic-Milacic, M, 2013-06-26 [InstanceEdit:3788093] Orlic-Milacic, M, 2013-07-04 [InstanceEdit:3788749] Orlic-Milacic, M, 2013-07-04 [InstanceEdit:3797211] Orlic-Milacic, M, 2013-07-05 [InstanceEdit:4542541] Matthews, L, 2013-09-05 [InstanceEdit:4612640] Orlic-Milacic, M, 2013-09-23 [InstanceEdit:4650052] Orlic-Milacic, M, 2013-10-01 [InstanceEdit:5093951] Orlic-Milacic, M, 2013-11-08 [InstanceEdit:5693290] Orlic-Milacic, Marija, 2015-05-14 [InstanceEdit:6810439] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8932753] Orlic-Milacic, Marija, 2016-07-28 [InstanceEdit:8932868] Orlic-Milacic, Marija, 2016-07-29 [InstanceEdit:8979059] Orlic-Milacic, Marija, 2017-02-21 [InstanceEdit:8979073] Orlic-Milacic, Marija, 2017-02-21 [InstanceEdit:8979103] Orlic-Milacic, Marija, 2017-02-21 [InstanceEdit:8979172] Orlic-Milacic, Marija, 2017-02-22 [InstanceEdit:8979190] Orlic-Milacic, Marija, 2017-02-22 [InstanceEdit:8979214] Orlic-Milacic, Marija, 2017-02-22 [InstanceEdit:9632714] Orlic-Milacic, Marija, 2018-12-20 [InstanceEdit:9638002] Orlic-Milacic, Marija, 2019-02-22 [InstanceEdit:9638003] Orlic-Milacic, Marija, 2019-02-22 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9645675] Orlic-Milacic, Marija, 2019-05-17 [InstanceEdit:9645676] Orlic-Milacic, Marija, 2019-05-17 [InstanceEdit:9645689] Orlic-Milacic, Marija, 2019-05-17 [InstanceEdit:9646308] Orlic-Milacic, Marija, 2019-05-22 [InstanceEdit:9658542] Orlic-Milacic, Marija, 2019-08-16 [InstanceEdit:9686321] May, Bruce, 2020-04-30 [InstanceEdit:9686777] May, Bruce, 2020-05-05 [InstanceEdit:9687794] May, Bruce, 2020-05-12 [InstanceEdit:9689767] Matthews, Lisa, 2020-05-21 [InstanceEdit:9689773] Matthews, Lisa, 2020-05-21 [InstanceEdit:9689793] Matthews, Lisa, 2020-05-21 [InstanceEdit:9689794] Matthews, Lisa, 2020-05-21 [InstanceEdit:9836729] Stephan, Ralf, 2023-06-01 [InstanceEdit:9840979] Stephan, Ralf, 2023-08-04 [InstanceEdit:9842006] Matthews, Lisa, 2023-08-16 [InstanceEdit:9842137] Stephan, Ralf, 2023-08-20 |
| representedPathway | [Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens] [Pathway:9632697] Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 [Homo sapiens] [Pathway:9632700] Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 [Homo sapiens] [Pathway:9646304] Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects [Homo sapiens] |
| storedATXML | <?xml version="1.0" encoding="UTF-8"?> <Process nextId="996" reactomeDiagramId="3214876"> <Properties> <displayName>Diagram of Oxidative Stress Induced Senescence, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, and Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects</displayName> </Properties> <Nodes> <org.gk.render.RenderableCompartment id="1" reactomeId="70101" position="785 786" bounds="52 27 1466 1518" textPosition="105 1215" bgColor="250 240 240" lineColor="255 153 102" insets="65 40 1436 1489"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="2" /> <Component id="48" /> <Component id="50" /> <Component id="52" /> <Component id="78" /> <Component id="124" /> <Component id="125" /> <Component id="126" /> <Component id="127" /> <Component id="128" /> <Component id="152" /> <Component id="49" /> <Component id="56" /> <Component id="216" /> <Component id="245" /> <Component id="254" /> <Component id="252" /> <Component id="253" /> <Component id="255" /> <Component id="256" /> <Component id="257" /> <Component id="258" /> <Component id="259" /> <Component id="260" /> <Component id="262" /> <Component id="263" /> <Component id="264" /> <Component id="265" /> <Component id="266" /> <Component id="308" /> <Component id="136" /> <Component id="312" /> <Component id="310" /> <Component id="309" /> <Component id="311" /> <Component id="322" /> <Component id="323" /> <Component id="324" /> <Component id="325" /> <Component id="326" /> <Component id="327" /> <Component id="328" /> <Component id="363" /> <Component id="364" /> <Component id="534" /> <Component id="647" /> <Component id="648" /> <Component id="796" /> <Component id="797" /> <Component id="799" /> <Component id="135" /> <Component id="800" /> <Component id="978" /> <Component id="798" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="2" reactomeId="7660" position="772 761" bounds="75 409 1394 705" textPosition="95 783" bgColor="250 240 240" lineColor="255 153 102" insets="87 418 1365 681"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="26" /> <Component id="44" /> <Component id="45" /> <Component id="46" /> <Component id="47" /> <Component id="137" /> <Component id="138" /> <Component id="139" /> <Component id="140" /> <Component id="159" /> <Component id="160" /> <Component id="161" /> <Component id="162" /> <Component id="185" /> <Component id="186" /> <Component id="187" /> <Component id="188" /> <Component id="147" /> <Component id="192" /> <Component id="189" /> <Component id="193" /> <Component id="191" /> <Component id="190" /> <Component id="200" /> <Component id="201" /> <Component id="202" /> <Component id="206" /> <Component id="207" /> <Component id="208" /> <Component id="209" /> <Component id="210" /> <Component id="214" /> <Component id="215" /> <Component id="220" /> <Component id="222" /> <Component id="221" /> <Component id="244" /> <Component id="261" /> <Component id="274" /> <Component id="136" /> <Component id="340" /> <Component id="349" /> <Component id="350" /> <Component id="351" /> <Component id="348" /> <Component id="339" /> <Component id="361" /> <Component id="362" /> <Component id="365" /> <Component id="366" /> <Component id="429" /> <Component id="431" /> <Component id="432" /> <Component id="433" /> <Component id="437" /> <Component id="438" /> <Component id="439" /> <Component id="440" /> <Component id="444" /> <Component id="445" /> <Component id="446" /> <Component id="447" /> <Component id="455" /> <Component id="532" /> <Component id="531" /> <Component id="533" /> <Component id="530" /> <Component id="448" /> <Component id="535" /> <Component id="536" /> <Component id="537" /> <Component id="541" /> <Component id="542" /> <Component id="543" /> <Component id="547" /> <Component id="548" /> <Component id="552" /> <Component id="553" /> <Component id="557" /> <Component id="558" /> <Component id="571" /> <Component id="572" /> <Component id="573" /> <Component id="646" /> <Component id="662" /> <Component id="663" /> <Component id="664" /> <Component id="665" /> <Component id="666" /> <Component id="668" /> <Component id="669" /> <Component id="686" /> <Component id="687" /> <Component id="688" /> <Component id="754" /> <Component id="755" /> <Component id="756" /> <Component id="758" /> <Component id="759" /> <Component id="760" /> <Component id="761" /> <Component id="762" /> <Component id="794" /> <Component id="795" /> <Component id="829" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="26" reactomeId="450213" position="903 559" bounds="836 542 135 35" textPosition="864 541" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-p38 MAPK: MAPKAPK2,3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="45" reactomeId="29358" position="979 608" bounds="958 598 42 20" textPosition="963 597" /> <org.gk.render.RenderableComplex id="46" reactomeId="450254" position="1138 572" bounds="1072 553 132 39" textPosition="1096 556" bgColor="204 255 255" lineWidth="1.0" hideComponents="true"> <Properties> <displayName>p-p38 MAPK:p-MAPKAPK2/3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="47" reactomeId="113582" position="1052 613" bounds="1033 602 38 23" textPosition="1036 602" /> <org.gk.render.RenderableChemical id="49" reactomeId="1250243" position="424 99" bounds="404 84 41 30" textPosition="408 88"> <Properties> <displayName>ROS</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="50" reactomeId="3225859" position="536 95" bounds="491 83 90 24" textPosition="495 85" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MAP3K5:TXN</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="52" reactomeId="167709" position="642 132" bounds="614 120 57 25" textPosition="615 121"> <Properties> <displayName>MAP3K5</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="56" reactomeId="3214892" position="431 146" bounds="404 130 54 32" textPosition="407 128"> <Properties> <displayName>MINK1/TNIK</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="125" reactomeId="113592" position="828 187" bounds="806 176 44 22" textPosition="812 176" /> <org.gk.render.RenderableEntitySet id="126" reactomeId="167916" position="764 130" bounds="720 113 88 34" textPosition="735 112"> <Properties> <displayName>MAP2K3,MAP2K6</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="127" reactomeId="29370" position="834 253" bounds="811 242 47 23" textPosition="819 242" /> <org.gk.render.RenderableEntitySet id="128" reactomeId="167984" position="761 309" bounds="700 286 123 46" textPosition="711 284"> <Properties> <displayName>p-S218,T222-MAP2K3, p-S207,T211-MAP2K6</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="136" reactomeId="450343" position="761 451" bounds="701 428 121 46" textPosition="711 426"> <Properties> <displayName>p-S189,T193-MAP2K3, p-S207,T211-MAP2K6</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="138" reactomeId="29358" position="708 600" bounds="687 589 42 23" textPosition="692 589" /> <org.gk.render.RenderableComplex id="139" reactomeId="450269" position="654 557" bounds="608 540 92 35" textPosition="614 539" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p38 MAPK:MAPKAPK2,3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="140" reactomeId="113582" position="832 609" bounds="812 597 40 25" textPosition="816 598" /> <org.gk.render.RenderableEntitySet id="147" reactomeId="198701" position="150 479" bounds="99 461 102 36" textPosition="113 461" bgColor="204 255 255"> <Properties> <displayName>p-T,Y MAPK dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableCompartment id="152" reactomeId="5460" position="242 103" bounds="166 72 153 63" textPosition="165 89" bgColor="250 240 240" lineColor="255 153 102" insets="174 84 137 41"> <Properties> <displayName>mitochondrial matrix</displayName> </Properties> <Components> <Component id="146" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="160" reactomeId="3229073" position="781 657" bounds="746 644 70 26" textPosition="757 648" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PRC1.4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="161" reactomeId="3222570" position="746 709" bounds="695 682 103 54" textPosition="703 686" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDKN2A Gene:H3K27Me3-Nucleosome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="162" reactomeId="3229098" position="969 694" bounds="891 671 156 46" textPosition="894 681" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="186" reactomeId="29358" position="1065 665" bounds="1046 654 39 23" textPosition="1049 654" /> <org.gk.render.RenderableComplex id="187" reactomeId="3229114" position="1221 705" bounds="1183 688 77 35" textPosition="1191 687" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-PRC1.4 complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="188" reactomeId="113582" position="1191 665" bounds="1173 654 37 23" textPosition="1176 654" /> <org.gk.render.RenderableChemical id="190" reactomeId="29358" position="147 528" bounds="127 515 40 26" textPosition="131 517" /> <org.gk.render.RenderableProtein id="191" reactomeId="450216" position="125 577" bounds="96 566 58 22" textPosition="110 566"> <Properties> <displayName>FOS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="192" reactomeId="113582" position="276 525" bounds="254 512 45 26" textPosition="261 514" /> <org.gk.render.RenderableProtein id="193" reactomeId="450283" position="321 581" bounds="278 547 87 69" textPosition="280 556"> <Properties> <displayName>p-T325,T331,S362,S374-FOS</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1839080459770115" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="450286" /> <org.gk.render.RenderableFeature relativeX="0.367816091954023" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="450356" /> <org.gk.render.RenderableFeature relativeX="0.5517241379310345" relativeY="0.0" label="P" description="Thr" trackId="0" reactomeId="450219" /> <org.gk.render.RenderableFeature relativeX="0.735632183908046" relativeY="0.0" label="P" description="Thr" trackId="0" reactomeId="450335" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="201" reactomeId="450237" position="468 643" bounds="408 630 121 26" textPosition="424 632"> <Properties> <displayName>p-S63,S73-JUN</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1322314049586777" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="168361" /> <org.gk.render.RenderableFeature relativeX="0.2644628099173554" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="450265" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="202" reactomeId="450327" position="381 693" bounds="297 682 169 23" textPosition="312 683" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-2S-cJUN:p-2S,2T-cFOS</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="207" reactomeId="3222526" position="268 822" bounds="222 797 92 51" textPosition="229 824"> <Properties> <displayName>KDM6B Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="208" reactomeId="3222535" position="423 757" bounds="354 738 138 38" textPosition="367 740" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-2S-cJUN:p-2S,2T-cFOS:KDM6B Gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="210" reactomeId="3222589" position="616 831" bounds="571 820 90 22" textPosition="577 820" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>KDM6B:Fe2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="215" reactomeId="3222592" position="745 901" bounds="695 884 100 35" textPosition="701 883" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDKN2A Gene:Nucleosome</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableRNA id="216" reactomeId="3209105" position="748 1153" bounds="686 1134 124 39" textPosition="698 1142"> <Properties> <displayName>p16INK4A mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableChemical id="221" reactomeId="113671" position="811 791" bounds="790 780 43 23" textPosition="795 780"> <Properties> <displayName>2OG</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="222" reactomeId="159939" position="824 862" bounds="793 849 63 26" textPosition="801 851"> <Properties> <displayName>SUCCA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableRNA id="245" reactomeId="3209107" position="945 1140" bounds="894 1122 103 37" textPosition="901 1129"> <Properties> <displayName>p14ARF mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableProtein id="253" reactomeId="182578" position="646 1215" bounds="604 1205 84 21" textPosition="615 1205"> <Properties> <displayName>p16INK4A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="254" reactomeId="3209131" position="918 1360" bounds="829 1335 179 50" textPosition="830 1349" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p16INK4A/p14ARF mRNA: miR-24 Nonendonucleolytic RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="256" reactomeId="69209" position="539 1347" bounds="496 1335 86 24" textPosition="503 1336"> <Properties> <displayName>CDK4,CDK6</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="257" reactomeId="182588" position="643 1286" bounds="616 1276 54 20" textPosition="626 1275"> <Properties> <displayName>INK4</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="259" reactomeId="182579" position="644 1456" bounds="570 1445 149 22" textPosition="595 1445" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CDK4,CDK6:INK4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="261" reactomeId="1629813" position="1015 1020" bounds="984 1009 63 22" textPosition="990 1009"> <Properties> <displayName>p14ARF</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="263" reactomeId="3209134" position="819 1273" bounds="758 1250 122 47" textPosition="760 1247" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>miR-24 Nonendonucleolytic RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="264" reactomeId="3209130" position="867 1210" bounds="779 1190 176 41" textPosition="794 1199"> <Properties> <displayName>p16INK4A/p14ARF mRNA</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="274" reactomeId="3209194" position="1255 797" bounds="1219 781 72 32" textPosition="1225 777" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="309" reactomeId="168107" position="572 174" bounds="542 164 60 21" textPosition="545 164"> <Properties> <displayName>MAP2K4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="310" reactomeId="113592" position="524 210" bounds="504 198 40 25" textPosition="508 199" /> <org.gk.render.RenderableProtein id="311" reactomeId="168170" position="570 290" bounds="491 277 159 26" textPosition="507 279"> <Properties> <displayName>p-S257,T261-MAP2K4</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.10062893081761007" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="450312" /> <org.gk.render.RenderableFeature relativeX="0.20125786163522014" relativeY="0.0" label="P" description="Thr" trackId="0" reactomeId="450354" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="312" reactomeId="29370" position="512 251" bounds="491 239 43 24" textPosition="497 240" /> <org.gk.render.RenderableEntitySet id="323" reactomeId="450289" position="269 382" bounds="223 370 92 25" textPosition="232 371"> <Properties> <displayName>MAPK8,9,10</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="324" reactomeId="113592" position="320 343" bounds="299 332 43 22" textPosition="304 332" /> <org.gk.render.RenderableEntitySet id="325" reactomeId="450226" position="475 384" bounds="419 372 113 24" textPosition="434 373"> <Properties> <displayName>p-MAPK8,9,10</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="326" reactomeId="29370" position="424 341" bounds="402 331 45 21" textPosition="409 331" /> <org.gk.render.RenderableEntitySet id="327" reactomeId="450299" position="365 289" bounds="294 275 142 29" textPosition="303 278"> <Properties> <displayName>p-MAP2K4/p-MAP2K7</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="340" reactomeId="450253" position="474 474" bounds="421 462 106 24" textPosition="432 463" /> <org.gk.render.RenderableChemical id="349" reactomeId="29358" position="414 547" bounds="394 536 41 22" textPosition="398 536"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="350" reactomeId="450250" position="469 512" bounds="448 502 43 21" textPosition="454 502"> <Properties> <displayName>JUN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="351" reactomeId="113582" position="405 600" bounds="383 589 44 22" textPosition="389 589" /> <org.gk.render.ProcessNode id="361" reactomeId="2559585" position="316 453" bounds="236 427 161 52" textPosition="256 431"> <Properties> <displayName>Oncogene Induced Senescence</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="363" reactomeId="453279" position="375 1449" bounds="279 1424 193 51" textPosition="293 1427"> <Properties> <displayName>Mitotic G1 phase and G1/S transition</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.ProcessNode id="365" reactomeId="109606" position="1406 744" bounds="1332 718 149 53" textPosition="1341 722"> <Properties> <displayName>Intrinsic Pathway for Apoptosis</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="431" reactomeId="3239002" position="831 515" bounds="795 497 73 36" textPosition="797 497" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p38 MAPK:MAPKAPK5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="432" reactomeId="113582" position="1010 461" bounds="990 450 40 22" textPosition="994 450" /> <org.gk.render.RenderableComplex id="433" reactomeId="3239009" position="1088 511" bounds="1020 493 137 36" textPosition="1029 493" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>phospho-p38 MAPK: MAPKAPK5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="438" reactomeId="29358" position="1175 466" bounds="1154 456 42 20" textPosition="1159 455" /> <org.gk.render.RenderableChemical id="439" reactomeId="113582" position="1250 468" bounds="1229 459 42 18" textPosition="1234 457" /> <org.gk.render.RenderableComplex id="440" reactomeId="3239017" position="1316 517" bounds="1251 493 130 49" textPosition="1253 506" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>phospho-p38 MAPK:p-T-182-MAPKAPK5</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="445" reactomeId="29358" position="1251 637" bounds="1230 627 43 21" textPosition="1235 627" /> <org.gk.render.RenderableComplex id="446" reactomeId="3239015" position="1392 675" bounds="1348 657 88 36" textPosition="1355 657" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S37-TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="447" reactomeId="113582" position="1341 625" bounds="1320 614 43 22" textPosition="1326 614"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="448" reactomeId="29358" position="876 467" bounds="856 457 40 20" textPosition="860 456" /> <org.gk.render.RenderableComplex id="455" reactomeId="212285" position="558 730" bounds="497 719 122 22" textPosition="504 719" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PRC2 (EZH2) Core</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="531" reactomeId="1227905" position="135 1013" bounds="96 981 78 64" textPosition="96 995" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>E2F1,E2F2,E2F3:TFDP1,TFDP2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="532" reactomeId="3240759" position="261 901" bounds="228 876 66 51" textPosition="231 903"> <Properties> <displayName>EED Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="533" reactomeId="3240767" position="391 853" bounds="337 834 109 38" textPosition="343 836" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EED Gene:E2F1/2/3:DP1/2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="536" reactomeId="3240762" position="249 963" bounds="212 938 74 51" textPosition="215 965"> <Properties> <displayName>EZH2 Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="537" reactomeId="3240771" position="387 936" bounds="331 918 113 36" textPosition="339 918" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>EZH2 Gene:E2F1/2/3:DP1/2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="542" reactomeId="3240760" position="231 1053" bounds="191 1028 80 51" textPosition="193 1055"> <Properties> <displayName>SUZ12 Gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="543" reactomeId="3240769" position="361 1024" bounds="306 1006 110 36" textPosition="313 1006" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SUZ12 Gene:E2F1/2/3:DP1/2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="548" reactomeId="212278" position="460 889" bounds="443 878 34 22" textPosition="445 878"> <Properties> <displayName>EED</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="553" reactomeId="212298" position="476 945" bounds="455 934 43 22" textPosition="457 934"> <Properties> <displayName>EZH2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="558" reactomeId="212217" position="464 1006" bounds="439 995 51 22" textPosition="442 995"> <Properties> <displayName>SUZ12</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="572" reactomeId="212223" position="484 1049" bounds="460 1038 49 22" textPosition="461 1038"> <Properties> <displayName>RBBP4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="573" reactomeId="212227" position="547 1046" bounds="523 1035 49 22" textPosition="524 1035"> <Properties> <displayName>RBBP7</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="646" reactomeId="3772127" position="1135 628" bounds="1077 610 117 37" textPosition="1077 611" bgColor="204 255 255" lineWidth="1.0" hideComponents="true"> <Properties> <displayName>phospho-MAPK p38:p-MAPKAPK3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="647" reactomeId="2559586" position="443 32" bounds="328 4 231 57" textPosition="327 10"> <Properties> <displayName>DNA Damage/Telomere Stress Induced Senescence</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="663" reactomeId="77087" position="595 794" bounds="566 780 59 29" textPosition="570 783"> <Properties> <displayName>AdoMet</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="664" reactomeId="77502" position="607 689" bounds="574 675 66 29" textPosition="582 678"> <Properties> <displayName>AdoHcy</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.ProcessNode id="665" reactomeId="2559582" position="176 695" bounds="91 657 171 77" textPosition="94 673"> <Properties> <displayName>Senescence-Associated Secretory Phenotype (SASP)</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableProtein id="667" reactomeId="877351" position="25 205" bounds="3 194 44 22" textPosition="5 194"> <Properties> <displayName>IFNB1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="668" reactomeId="69620" position="1408 821" bounds="1327 795 163 53" textPosition="1339 806"> <Properties> <displayName>Cell Cycle Checkpoints</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableComplex id="687" reactomeId="6804885" position="1173 1031" bounds="1100 1002 147 58" textPosition="1115 1010" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="688" reactomeId="6804999" position="1040 905" bounds="959 880 163 51" textPosition="959 881" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4:TP53</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="755" reactomeId="68524" position="1183 928" bounds="1154 917 59 22" textPosition="1172 917"> <Properties> <displayName>Ub</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="756" reactomeId="3209186" position="1362 899" bounds="1319 882 87 34" textPosition="1322 880" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PolyUb-TP53 Tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="759" reactomeId="6804995" position="1213 860" bounds="1144 830 139 61" textPosition="1151 841" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p14ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="760" reactomeId="6804745" position="1369 995" bounds="1309 963 121 64" textPosition="1311 970" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableGene id="761" reactomeId="3200017" position="695 972" bounds="648 947 94 51" textPosition="653 974"> <Properties> <displayName>CDKN2A gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="762" reactomeId="1629833" position="497 820" bounds="472 809 51 22" textPosition="473 809"> <Properties> <displayName>KDM6B</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="795" reactomeId="111793" position="585 903" bounds="564 889 42 28" textPosition="567 892"> <Properties> <displayName>Fe2+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.ProcessNode id="796" reactomeId="6802957" position="88 35" bounds="27 7 123 57" textPosition="32 13" bgColor="204 255 204" fgColor="255 51 51" lineColor="255 0 0" lineWidth="1.0" isForDisease="true"> <Properties> <displayName>Oncogenic MAPK signaling</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="799" reactomeId="8979184" position="331 232" bounds="289 215 85 34" textPosition="292 214"> <Properties> <displayName>MINK1/TNIK genes</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="800" reactomeId="9645669" position="1139 1166" bounds="1112 1155 55 22" textPosition="1114 1155" /> <org.gk.render.RenderableProtein id="978" reactomeId="73668" position="435 203" bounds="392 186 87 34" textPosition="403 192"> <Properties> <displayName>2xHC-TXN</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1839080459770115" relativeY="0.0" label="SS" trackId="0" reactomeId="111706" /> </NodeAttachments> </org.gk.render.RenderableProtein> </Nodes> <Edges> <org.gk.render.RenderableReaction id="44" reactomeId="450222" points="999 564, 1017 564, 1038 564" position="1017 564" lineWidth="1.0"> <Inputs> <Input id="26" points="974 562" /> <Input id="45" stoichiometry="3" points="983 595" /> </Inputs> <Outputs> <Output id="46" points="1069 566" /> <Output id="47" stoichiometry="3" points="1048 599" /> </Outputs> <Catalysts> <Catalyst id="26" points="974 543, 1001 537" /> </Catalysts> <Properties> <displayName>Active p38 MAPK phosphorylates MAPKAPK2 or 3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="48" reactomeId="3225851" points="488 126, 489 147, 489 169" position="489 147" lineWidth="1.0"> <Inputs> <Input id="49" points="448 107" /> <Input id="50" points="517 110" /> </Inputs> <Outputs> <Output id="52" points="611 138" /> <Output id="978" points="462 183" /> </Outputs> <Activators> <Activator id="56" points="464 146" /> </Activators> <Properties> <displayName>ROS oxidize thioredoxin and activate MAP3K5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="78" reactomeId="3225867" points="338 209, 366 155, 398 149" position="366 155" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="799" /> </Inputs> <Outputs> <Output id="56" /> </Outputs> <Activators> <Activator id="49" points="401 110, 378 124" /> </Activators> <Properties> <displayName>Expression of MINK1/TNIK is positively regulated by ROS</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="124" reactomeId="3228469" points="762 188, 762 226, 761 253" position="762 226" lineWidth="1.0"> <Inputs> <Input id="125" stoichiometry="2" points="803 187" /> <Input id="126" points="763 153" /> </Inputs> <Outputs> <Output id="127" stoichiometry="2" points="808 253" /> <Output id="128" points="761 280" /> </Outputs> <Catalysts> <Catalyst id="52" points="646 148, 675 227" /> </Catalysts> <Properties> <displayName>MAP3K5 phosphorylates MKK3 and MKK6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="135" reactomeId="450296" points="760 338, 759 378, 760 422" position="759 378" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="128" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> <Properties> <displayName>Phosphorylated MKK3/MKK6 migrates to nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="137" reactomeId="450333" points="736 558, 761 559, 793 558" position="761 559" lineWidth="1.0"> <Inputs> <Input id="138" stoichiometry="2" points="715 586" /> <Input id="139" points="703 557" /> </Inputs> <Outputs> <Output id="26" points="833 558" /> <Output id="140" stoichiometry="2" points="822 594" /> </Outputs> <Catalysts> <Catalyst id="136" points="761 480" /> </Catalysts> <Properties> <displayName>Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="3223236" points="277 117, 314 126, 401 104" position="314 126" lineWidth="1.0" reactionType="Omitted Process"> <Outputs> <Output id="49" /> </Outputs> <Activators> <Activator id="147" points="158 455" /> <Activator id="667" points="50 204, 189 201" /> </Activators> <Properties> <displayName>RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="159" reactomeId="3229089" points="854 692, 851 692, 888 692" position="851 692" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="160" points="808 673" /> <Input id="161" points="801 700" /> </Inputs> <Outputs> <Output id="162" /> </Outputs> <Properties> <displayName>PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="185" reactomeId="3229102" points="1072 693, 1134 694, 1154 694" position="1134 694" lineWidth="1.0"> <Inputs> <Input id="162" points="1050 693" /> <Input id="186" points="1067 680" /> </Inputs> <Outputs> <Output id="187" points="1180 698" /> <Output id="188" points="1176 680" /> <Output id="161" points="801 727, 833 741, 1124 741" /> </Outputs> <Catalysts> <Catalyst id="646" points="1134 650" /> </Catalysts> <Properties> <displayName>p-MAPKAPK3 phosphorylates BMI1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="189" reactomeId="450325" points="183 578, 206 578, 235 577" position="206 578" lineWidth="1.0"> <Inputs> <Input id="190" stoichiometry="4" points="156 544" /> <Input id="191" points="157 577" /> </Inputs> <Outputs> <Output id="192" stoichiometry="4" points="265 541" /> <Output id="193" points="275 578" /> </Outputs> <Catalysts> <Catalyst id="147" points="174 503, 204 519" /> </Catalysts> <Properties> <displayName>c-FOS activation by phospho ERK1/2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="200" reactomeId="450292" points="365 646, 365 645, 377 679" position="365 645" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="201" points="405 644" /> <Input id="193" points="344 619" /> </Inputs> <Outputs> <Output id="202" /> </Outputs> <Properties> <displayName>Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="206" reactomeId="3222533" points="314 752, 316 752, 351 753" position="316 752" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="207" points="323 799" /> <Input id="202" points="367 708" /> </Inputs> <Outputs> <Output id="208" /> </Outputs> <Properties> <displayName>ERK1/2-activated AP1 complex binds KDM6B promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="209" reactomeId="3222546" points="323 799, 422 810, 469 816" position="422 810" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="207" /> </Inputs> <Outputs> <Output id="762" /> </Outputs> <Activators> <Activator id="208" points="422 779" /> </Activators> <Properties> <displayName>AP-1 complex stimulates KDM6B transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="214" reactomeId="3223200" points="751 949, 750 1039, 748 1139" position="750 1039" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="761" /> </Inputs> <Outputs> <Output id="216" /> </Outputs> <Inhibitors> <Inhibitor id="162" points="960 720, 847 1041" /> </Inhibitors> <Activators> <Activator id="210" points="616 845, 619 1034" /> </Activators> <Properties> <displayName>Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="220" reactomeId="3222593" points="746 794, 745 831, 745 857" position="745 831" lineWidth="1.0"> <Inputs> <Input id="221" stoichiometry="3" points="787 791" /> <Input id="161" points="746 739" /> </Inputs> <Outputs> <Output id="222" stoichiometry="3" points="790 860" /> <Output id="215" points="745 881" /> </Outputs> <Catalysts> <Catalyst id="210" points="664 831" /> </Catalysts> <Properties> <displayName>KDM6B demethylates H3K27me3 on p16INK4A promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="244" reactomeId="3229138" points="751 949, 941 889, 944 1127" position="941 889" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="761" /> </Inputs> <Outputs> <Output id="245" /> </Outputs> <Activators> <Activator id="646" points="1121 650" /> </Activators> <Properties> <displayName>MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="252" reactomeId="3209114" points="747 1168, 747 1210, 691 1212" position="747 1210" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="216" /> </Inputs> <Outputs> <Output id="253" /> </Outputs> <Inhibitors> <Inhibitor id="254" points="826 1345, 748 1333" /> </Inhibitors> <Properties> <displayName>Translation of p16INK4A mRNA is inhibited by miR-24</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="255" reactomeId="182594" points="644 1366, 643 1402, 643 1442" position="643 1402" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="256" points="588 1354" /> <Input id="257" points="643 1302" /> </Inputs> <Outputs> <Output id="259" /> </Outputs> <Properties> <displayName>Association of INK4 family proteins with CDK4/6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="258" points="645 1229, 643 1270" position="644 1249" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="253" /> </Inputs> <Outputs> <Output id="257" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="260" reactomeId="3209111" points="977 1154, 1061 1207, 1118 1180" position="1061 1207" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="245" /> </Inputs> <Outputs> <Output id="800" /> </Outputs> <Inhibitors> <Inhibitor id="254" points="1011 1350, 1062 1344" /> </Inhibitors> <Properties> <displayName>Translation of p14ARF mRNA is inhibited by miR-24</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="262" reactomeId="3209151" points="941 1271, 936 1297, 925 1332" position="936 1297" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="263" points="883 1272" /> <Input id="264" points="891 1237" /> </Inputs> <Outputs> <Output id="254" /> </Outputs> <Properties> <displayName>miR-24 binds p16INK4A and p14ARF mRNAs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="265" points="802 1168, 835 1184" position="818 1176" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="216" /> </Inputs> <Outputs> <Output id="264" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="266" points="920 1154, 886 1184" position="903 1169" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="245" /> </Inputs> <Outputs> <Output id="264" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="308" reactomeId="3229152" points="571 212, 571 231, 570 250" position="571 231" lineWidth="1.0"> <Inputs> <Input id="309" points="571 188" /> <Input id="310" stoichiometry="2" points="547 210" /> </Inputs> <Outputs> <Output id="311" points="570 274" /> <Output id="312" stoichiometry="2" points="537 250" /> </Outputs> <Catalysts> <Catalyst id="52" points="638 148, 614 230" /> </Catalysts> <Properties> <displayName>MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="322" reactomeId="168162" points="343 382, 366 383, 384 382" position="366 383" lineWidth="1.0"> <Inputs> <Input id="323" points="321 382" /> <Input id="324" stoichiometry="2" points="326 357" /> </Inputs> <Outputs> <Output id="325" points="413 382" /> <Output id="326" stoichiometry="2" points="413 355" /> </Outputs> <Catalysts> <Catalyst id="327" points="365 310" /> </Catalysts> <Properties> <displayName>Phosphorylation of human JNKs by activated MKK4/MKK7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="328" points="488 289, 442 289" position="465 289" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="311" /> </Inputs> <Outputs> <Output id="327" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="339" reactomeId="450348" points="474 402, 474 416, 474 456" position="474 416" lineWidth="1.0"> <Inputs> <Input id="325" /> </Inputs> <Outputs> <Output id="340" /> </Outputs> <Properties> <displayName>Activated human JNKs migrate to nucleoplasm</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="348" reactomeId="168136" points="469 557, 468 583, 468 604" position="468 583" lineWidth="1.0"> <Inputs> <Input id="349" stoichiometry="2" points="438 550" /> <Input id="350" points="469 526" /> </Inputs> <Outputs> <Output id="201" points="468 627" /> <Output id="351" stoichiometry="2" points="430 601" /> </Outputs> <Catalysts> <Catalyst id="340" points="485 492, 506 507, 503 583" /> </Catalysts> <Properties> <displayName>Activated JNKs phosphorylate c-JUN</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="362" interactionType="Activate" points="207 469, 233 464" position="220 466" lineWidth="2.0"> <Inputs> <Input id="147" /> </Inputs> <Outputs> <Output id="361" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="364" interactionType="Activate" points="567 1453, 475 1451" position="521 1452" lineWidth="2.0"> <Inputs> <Input id="259" /> </Inputs> <Outputs> <Output id="363" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="366" interactionType="Activate" points="1294 783, 1329 769" position="1311 776" lineWidth="2.0"> <Inputs> <Input id="274" /> </Inputs> <Outputs> <Output id="365" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="429" reactomeId="3238999" points="923 513, 946 513, 973 514" position="946 513" lineWidth="1.0"> <Inputs> <Input id="448" stoichiometry="2" points="886 480" /> <Input id="431" points="871 514" /> </Inputs> <Outputs> <Output id="432" stoichiometry="2" points="1002 475" /> <Output id="433" points="1017 512" /> </Outputs> <Catalysts> <Catalyst id="136" points="828 448, 942 443" /> </Catalysts> <Properties> <displayName>Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="437" reactomeId="3239019" points="1193 511, 1211 512, 1226 510" position="1211 512" lineWidth="1.0"> <Inputs> <Input id="438" points="1179 479" /> <Input id="433" points="1160 511" /> </Inputs> <Outputs> <Output id="439" points="1244 480" /> <Output id="440" points="1248 511" /> </Outputs> <Catalysts> <Catalyst id="433" points="1160 524, 1196 533" /> </Catalysts> <Properties> <displayName>Active p38 MAPK phosphorylates MAPKAPK5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="444" reactomeId="3239014" points="1277 670, 1298 670, 1317 670" position="1298 670" lineWidth="1.0"> <Inputs> <Input id="445" stoichiometry="4" points="1259 651" /> <Input id="274" points="1257 778" /> </Inputs> <Outputs> <Output id="446" points="1345 672" /> <Output id="447" stoichiometry="4" points="1335 639" /> </Outputs> <Catalysts> <Catalyst id="440" points="1313 545" /> </Catalysts> <Properties> <displayName>MAPKAPK5 phosphorylates TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="530" reactomeId="3240765" points="146 868, 146 868, 334 856" position="146 868" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="531" points="137 978" /> <Input id="532" points="303 878" /> </Inputs> <Outputs> <Output id="533" /> </Outputs> <Properties> <displayName>E2F1/2/3:DP1/2 binds EED gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="534" interactionType="Activate" points="360 1421, 152 1048" position="256 1234" lineWidth="2.0"> <Inputs> <Input id="363" /> </Inputs> <Outputs> <Output id="531" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="535" reactomeId="3240777" points="164 918, 164 917, 328 931" position="164 917" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="531" points="144 978" /> <Input id="536" points="295 940" /> </Inputs> <Outputs> <Output id="537" /> </Outputs> <Properties> <displayName>E2F1/2/3:DP1/2 binds EZH2 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="541" reactomeId="3240766" points="197 1003, 196 1003, 303 1017" position="196 1003" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="531" points="177 1006" /> <Input id="542" points="280 1030" /> </Inputs> <Outputs> <Output id="543" /> </Outputs> <Properties> <displayName>E2F1/2/3:DP1/2 binds SUZ12 gene promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="547" reactomeId="3240782" points="303 878, 390 902, 440 892" position="390 902" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="532" /> </Inputs> <Outputs> <Output id="548" /> </Outputs> <Activators> <Activator id="533" points="390 875" /> </Activators> <Properties> <displayName>E2F1/2/3 stimulates EED transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="552" reactomeId="3240783" points="295 940, 386 993, 455 959" position="386 993" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="536" /> </Inputs> <Outputs> <Output id="553" /> </Outputs> <Activators> <Activator id="537" points="386 957" /> </Activators> <Properties> <displayName>E2F1/2/3 stimulates EZH2 transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="557" reactomeId="3240787" points="280 1030, 362 1084, 449 1020" position="362 1084" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="542" /> </Inputs> <Outputs> <Output id="558" /> </Outputs> <Activators> <Activator id="543" points="361 1045" /> </Activators> <Properties> <displayName>E2F1/2/3 stimulates SUZ12 transcription</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="571" reactomeId="3240957" points="552 906, 552 906, 557 744" position="552 906" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="572" points="489 1035" /> <Input id="553" points="497 931" /> <Input id="548" points="480 892" /> <Input id="558" points="473 992" /> <Input id="573" points="547 1032" /> </Inputs> <Outputs> <Output id="455" /> </Outputs> <Properties> <displayName>Formation of PRC2-EZH2 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="648" interactionType="Activate" points="428 81, 434 64" position="431 72" lineWidth="2.0"> <Inputs> <Input id="49" /> </Inputs> <Outputs> <Output id="647" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="662" reactomeId="3240295" points="663 798, 663 769, 660 724" position="663 769" lineWidth="1.0"> <Inputs> <Input id="663" stoichiometry="6" points="628 795" /> <Input id="215" points="731 881" /> </Inputs> <Outputs> <Output id="161" points="692 717" /> <Output id="664" stoichiometry="6" points="628 707" /> </Outputs> <Catalysts> <Catalyst id="455" points="587 744" /> </Catalysts> <Properties> <displayName>PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="666" interactionType="Activate" points="294 692, 265 692" position="279 692" lineWidth="2.0"> <Inputs> <Input id="202" /> </Inputs> <Outputs> <Output id="665" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="669" interactionType="Activate" points="1294 802, 1324 807" position="1309 804" lineWidth="2.0"> <Inputs> <Input id="274" /> </Inputs> <Outputs> <Output id="668" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="686" reactomeId="6804998" points="1063 980, 1048 958, 1043 934" position="1048 958" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="687" points="1110 999" /> <Input id="261" points="1028 1006" /> </Inputs> <Outputs> <Output id="688" /> </Outputs> <Properties> <displayName>p14ARF forms a ternary complex with MDM2 and TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="754" reactomeId="6804879" points="1222 975, 1253 952, 1282 930" position="1253 952" lineWidth="1.0"> <Inputs> <Input id="687" points="1198 999" /> <Input id="755" stoichiometry="12" points="1192 945" /> </Inputs> <Outputs> <Output id="760" points="1326 957" /> <Output id="756" points="1316 915" /> </Outputs> <Catalysts> <Catalyst id="687" points="1228 999, 1249 991" /> </Catalysts> <Inhibitors> <Inhibitor id="759" points="1226 894" /> </Inhibitors> <Properties> <displayName>MDM2 ubiquitinates TP53</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="758" reactomeId="6804996" points="1088 877, 1125 860, 1132 797" position="1125 860" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="688" /> </Inputs> <Outputs> <Output id="274" points="1216 797" /> <Output id="759" points="1173 827" /> </Outputs> <Properties> <displayName>p14ARF sequesters MDM2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="794" reactomeId="8979071" points="560 865, 575 857, 598 845" position="575 857" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="762" points="512 834" /> <Input id="795" points="575 886" /> </Inputs> <Outputs> <Output id="210" /> </Outputs> <Properties> <displayName>KDM6B binds iron</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="797" interactionType="Activate" points="92 67, 147 455" position="119 261" lineWidth="2.0" lineColor="255 51 51"> <Inputs> <Input id="796" /> </Inputs> <Outputs> <Output id="147" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="798" interactionType="Activate" points="153 34, 325 32" position="239 33" lineWidth="2.0" lineColor="255 51 51"> <Inputs> <Input id="796" /> </Inputs> <Outputs> <Output id="647" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="829" reactomeId="9645672" points="1129 1152, 1077 1093, 1024 1034" position="1077 1093" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="800" /> </Inputs> <Outputs> <Output id="261" /> </Outputs> <Properties> <displayName>p14ARF translocates to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="976" interactionType="Activate" points="1170 1166, 1551 1167, 1548 746, 1484 745" position="1549 956" lineWidth="2.0"> <Inputs> <Input id="800" /> </Inputs> <Outputs> <Output id="365" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process> |
| width | 1565 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Diagram of Oxidative Stress Induced Senescence, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, and Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects (3214876)
