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Details on Person ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Class:Id	LiteratureReference:3209191
_displayName	ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
_timestamp	2013-03-01 21:18:29
author	[Person:113950] Zhang, Y [Person:3209193] Xiong, Y [Person:3209188] Yarbrough, W G
created	[InstanceEdit:3209187] Orlic-Milacic, M, 2013-03-01
journal	Cell
pages	725-34
pubMedIdentifier	9529249
title	ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
volume	92
year	1998
(literatureReference)	[Pathway:2559580] Oxidative Stress Induced Senescence [Homo sapiens] [Pathway:2559585] Oncogene Induced Senescence [Homo sapiens] [Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens] [Reaction:6804996] p14ARF sequesters MDM2 [Homo sapiens] [Reaction:6804998] p14ARF forms a ternary complex with MDM2 and TP53 [Homo sapiens] [Pathway:6806003] Regulation of TP53 Expression and Degradation [Homo sapiens] [RegulationReference:9642183] Negative regulation by 'p14-ARF:p-S166,S188-MDM2 dimer,p-S166,S188-MDM2:MDM4 [nucleoplasm]' ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
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